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Group of antidepressants
This article is about a series of antidepressants. For the toxic, unstable compound with the chemical formula N
2 H
4 , see
hydrazine .
Iproniazid , the first hydrazine MAOI to be discovered.
The hydrazine
antidepressants are a group of non-selective,
irreversible
monoamine oxidase inhibitors (MAOIs) which were discovered and initially marketed in the 1950s and 1960s. Most have been withdrawn due to
toxicity , namely
hepatotoxicity , but a few still remain in clinical use.
Tranylcypromine , a structurally unrelated MAOI introduced around the same time as the hydrazines, was originally advertised as non-hydrazine as a result of its diminished propensity for causing
hepatotoxicity .
List of hydrazine antidepressants
Marketed
Legend: ‡ = Withdrawn from the market; † = Partially discontinued; Bolded names indicate major drugs.
Never marketed
Tranquillosedative
References
SSRIs Tooltip Selective serotonin reuptake inhibitors
SNRIs Tooltip Serotonin–norepinephrine reuptake inhibitors
NRIs Tooltip Norepinephrine reuptake inhibitors
NDRIs Tooltip Norepinephrine–dopamine reuptake inhibitors
NaSSAs Tooltip Noradrenergic and specific serotonergic antidepressants
SARIs Tooltip Serotonin antagonist and reuptake inhibitors
SMS Tooltip Serotonin modulator and stimulators Others
TCAs Tooltip Tricyclic antidepressants
TeCAs Tooltip Tetracyclic antidepressants Others
Non-selective
MAOA Tooltip Monoamine oxidase A -selective
MAOB Tooltip Monoamine oxidase B -selective