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Family of viral proteins
The Epstein–Barr virus nuclear antigen 3 (EBNA-3) is a family of
viral proteins associated with the
Epstein–Barr virus . A typical EBV genome contains three such proteins:
[1]
EBNA-3A (
P12977 , EBNA-3; BLRF3-BERF1)
EBNA-3B (
P03203 , EBNA-4; BERF2A-BERF2B)
EBNA-3C (
P03204 , EBNA-6, EBNA-4B; BERF3-BERF4)
These genes also bind the host
RBP-Jκ protein.
[2]
EBNA-3C can recruit a
ubiquitin
ligase and has been shown to target cell-cycle regulators such as
retinoblastoma protein (pRb).
[3]
[4]
References
^ Jiang, H; Cho, YG; Wang, F (July 2000).
"Structural, functional, and genetic comparisons of Epstein-Barr virus nuclear antigen 3A, 3B, and 3C homologues encoded by the rhesus lymphocryptovirus" . Journal of Virology . 74 (13): 5921–32.
doi :
10.1128/jvi.74.13.5921-5932.2000 .
PMC
112088 .
PMID
10846073 .
^ Kalchschmidt, JS; Gillman, AC; Paschos, K; Bazot, Q; Kempkes, B; Allday, MJ (January 2016).
"EBNA3C Directs Recruitment of RBPJ (CBF1) to Chromatin during the Process of Gene Repression in EBV Infected B Cells" . PLOS Pathogens . 12 (1): e1005383.
doi :
10.1371/journal.ppat.1005383 .
PMC
4708995 .
PMID
26751214 .
^
Knight JS, Sharma N, Robertson ES (2005).
"SCFSkp2 complex targeted by Epstein-Barr virus essential nuclear antigen" . Mol. Cell. Biol . 25 (5): 1749–63.
doi :
10.1128/MCB.25.5.1749-1763.2005 .
PMC
549383 .
PMID
15713632 .
^ Knight JS, Sharma N, Robertson ES (2005).
"Epstein-Barr virus latent antigen 3C can mediate the degradation of the retinoblastoma protein through an SCF cellular ubiquitin ligase" . Proc. Natl. Acad. Sci. U.S.A . 102 (51): 18562–6.
Bibcode :
2005PNAS..10218562K .
doi :
10.1073/pnas.0503886102 .
PMC
1317900 .
PMID
16352731 .