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Alpha trans-inducing protein (Alpha-TIF)
Structure of the conserved core of the herpes simplex virus transcriptional regulatory protein VP16. [1]
Identifiers
SymbolAlpha_TIF
Pfam PF02232
InterPro IPR003174
SMART SM00814
SCOP2 16vp / SCOPe / SUPFAM
Available protein structures:
Pfam   structures / ECOD  
PDB RCSB PDB; PDBe; PDBj
PDBsum structure summary
PDB 16vp​

Vmw65, also known as VP16 or α-TIF (Trans Inducing Factor) [2] is a trans-acting protein that forms a complex with the host transcription factors Oct-1 and HCF to induce immediate early gene transcription in the herpes simplex viruses. [3] [4]

VP16 is a strong transactivator [5] and is often used in Y2H systems as the activation domain of the system. [6]

References

  1. ^ Liu Y, Gong W, Huang CC, Herr W, Cheng X (July 1999). "Crystal structure of the conserved core of the herpes simplex virus transcriptional regulatory protein VP16". Genes Dev. 13 (13): 1692–703. doi: 10.1101/gad.13.13.1692. PMC  316849. PMID  10398682.
  2. ^ Entry for Vmw65 on Cure hunter
  3. ^ O'Reilly D, Hanscombe O, O'Hare P (May 1997). "A single serine residue at position 375 of VP16 is critical for complex assembly with Oct-1 and HCF and is a target of phosphorylation by casein kinase II". EMBO J. 16 (9): 2420–30. doi: 10.1093/emboj/16.9.2420. PMC  1169842. PMID  9171355.
  4. ^ Wysocka J, Herr W (June 2003). "The herpes simplex virus VP16-induced complex: the makings of a regulatory switch". Trends Biochem. Sci. 28 (6): 294–304. doi: 10.1016/S0968-0004(03)00088-4. PMID  12826401.
  5. ^ Hirai, Hiroyuki; Tani, Tetsuya; Kikyo, Nobuaki (2010). "Structure and functions of powerful transactivators: VP16, MyoD and FoxA". The International Journal of Developmental Biology. 54 (11–12): 1589–1596. doi: 10.1387/ijdb.103194hh. PMC  3419751. PMID  21404180.
  6. ^ Stynen, B.; Tournu, H.; Tavernier, J.; Van Dijck, P. (11 June 2012). "Diversity in Genetic In Vivo Methods for Protein-Protein Interaction Studies: from the Yeast Two-Hybrid System to the Mammalian Split-Luciferase System". Microbiology and Molecular Biology Reviews. 76 (2): 331–382. doi: 10.1128/MMBR.05021-11. PMC  3372256. PMID  22688816.


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