From Wikipedia, the free encyclopedia
Epstein–Barr virus latent membrane protein 1 (LMP1 ) is an
Epstein–Barr virus (EBV) protein that regulates its own expression and the expression of human genes.
[1] It has a
molecular weight of approximately 63
kDa , and its expression induces many of the changes associated with EBV infections and activation of primary
B cells .
[2] LMP1 is the best-documented
oncoprotein of the EBV latent
gene products , as it is expressed in most EBV-related human cancers
[3] such as the various malignant
Epstein-Barr virus-associated lymphoproliferative diseases .
[4]
The structure of LMP1 consists of a short cytoplasmic
terminal tail , six
trans-membrane domains , and a long
cytoplasmic
C-terminus , which contains three activating domains: CTARt, CTAR2, and CTAR3. Each CTAR domain contains an amino acid sequence that serves as a recognition site for cellular adaptors to bind and trigger a series of
signal transduction pathways that can lead to a change in
gene expression .
[5]
LMP-1 is a functional homologue of
tumor necrosis factor
[6] and mediates signaling through the
nuclear factor-κB pathway, mimicking
CD40 receptor signaling.
[1]
[3]
It is often found in the malignant
Reed–Sternberg cells of
Hodgkin lymphoma ,
[7]
[8] the malignant
B cells of
EBV-associated B cell lymphatic cancers , and the malignant
NK cells of
NK/T cell lymphatic cancers .
[4]
References
^
a
b Pratt, Z; Zhang, J; Sugden, B. (2012).
"The latent membrane protein 1 (LMP1) oncogene of Epstein–Barr virus can simultaneously induce and inhibit apoptosis in B cells" . Journal of Virology . 86 (8): 4380–4393.
doi :
10.1128/JVI.06966-11 .
PMC
3318665 .
PMID
22318153 .
^ Gupta (2011).
"Latent Membrane Protein 1 as a molecular adjuvant for single-cycle lentiviral vaccines" . Retrovirology . 8 (1): 39.
doi :
10.1186/1742-4690-8-39 .
PMC
3118346 .
PMID
21592361 .
^
a
b Ersing, I; Bernhardt, K; Gewurz, BE (Jun 21, 2013).
"NF-κB and IRF7 pathway activation by Epstein-Barr virus Latent Membrane Protein 1" . Viruses . 5 (6) (6 ed.): 1587–606.
doi :
10.3390/v5061587 .
PMC
3717723 .
PMID
23793113 .
^
a
b Rezk SA, Zhao X, Weiss LM (June 2018). "Epstein - Barr virus - associated lymphoid proliferations, a 2018 update". Human Pathology . 79 : 18–41.
doi :
10.1016/j.humpath.2018.05.020 .
PMID
29885408 .
S2CID
47010934 .
^ Li, H.; Chang, Y. (2003). "Epstein–barr virus latent membrane protein 1: Structure and functions". J. Biomed. Sci . 10 (5): 490–504.
doi :
10.1159/000072376 .
PMID
12928589 .
S2CID
202646382 .
^ Cameron, J. E.; Yin, Q; Fewell, C; Lacey, M; McBride, J; Wang, X; Lin, Z; Schaefer, B. C.; Flemington, E. K. (2008).
"Epstein-Barr virus latent membrane protein 1 induces cellular MicroRNA miR-146a, a modulator of lymphocyte signaling pathways" . Journal of Virology . 82 (4): 1946–58.
doi :
10.1128/JVI.02136-07 .
PMC
2258704 .
PMID
18057241 .
^ Herling M, Rassidakis GZ, Medeiros LJ, et al. (June 2003).
"Expression of Epstein–Barr virus latent membrane protein-1 in Hodgkin and Reed-Sternberg cells of classical Hodgkin's lymphoma: associations with presenting features, serum interleukin 10 levels, and clinical outcome" . Clin. Cancer Res . 9 (6): 2114–20.
PMID
12796376 .
^ Andersson J (May 2006). "Epstein–Barr virus and Hodgkin's lymphoma". Herpes . 13 (1): 12–6.
PMID
16732997 .