Nonstructural protein 3 (NS3), also known as p-70, is a viral nonstructural protein that is 70 kDa cleavage product of the hepatitis C virus polyprotein. It acts as a serine protease. [1] [2] C-terminal two-thirds of the protein also acts as helicase and nucleoside triphosphatase. [3] First (N-terminal) 180 aminoacids of NS3 has additional role as cofactor domains for NS2 protein. [4]
See also
- Boceprevir, sovaprevir, paritaprevir and telaprevir - drugs targeting this protein [5]
References
- ^ Hijikata, M.; et al. (1993). "Proteolytic processing and membrane association of putative nonstructural proteins of hepatitis C virus". Proc. Natl. Acad. Sci. USA. 90 (22): 10773–10777. Bibcode: 1993PNAS...9010773H. doi: 10.1073/pnas.90.22.10773. PMC 47860. PMID 7504283.
- ^ Raney, Kevin D.; Sharma, Suresh D.; Moustafa, Ibrahim M.; Cameron, Craig E. (2010). "Hepatitis C Virus Non-structural Protein 3 (HCV NS3): A Multifunctional Antiviral Target". Journal of Biological Chemistry. 285 (30): 22725–22731. doi: 10.1074/jbc.R110.125294. PMC 2906261. PMID 20457607.
- ^ Stimulation of Hepatitis C Virus (HCV) Nonstructural Protein 3 (NS3) Helicase Activity by the NS3 Protease Domain and by HCV RNA-Dependent RNA Polymerase / J. Virol. July 2005 vol. 79 no. 14 8687-8697
- ^ Schregel, V; Jacobi, S; Penin, F; Tautz, N (2009). "Hepatitis C virus NS2 is a protease stimulated by cofactor domains in NS3". Proc Natl Acad Sci U S A. 106 (13): 5342–7. Bibcode: 2009PNAS..106.5342S. doi: 10.1073/pnas.0810950106. PMC 2663979. PMID 19282477.
- ^ "NS3/4A Protease Inhibitors - DrugBank".
External links
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