From Wikipedia, the free encyclopedia
Protein-coding gene in the species Homo sapiens
Putative tyrosine-protein phosphatase auxilin is an
enzyme that in humans is encoded by the DNAJC6
gene .
[5]
[6]
[7]
Function
DNAJC6 belongs to the evolutionarily conserved DNAJ/HSP40 family of proteins, which regulate molecular chaperone activity by stimulating ATPase activity. DNAJ proteins may have up to 3 distinct domains: a conserved 70-amino acid J domain, usually at the N terminus, a glycine/phenylalanine (G/F)-rich region, and a cysteine-rich domain containing 4 motifs resembling a zinc-finger domain (Ohtsuka and Hata, 2000).
[7]
Structure
The
protein tyrosine phosphatase domain and
C2 domain pair of auxilin, located near the N-terminus of the polypeptide, constitute a superdomain, a tandem arrangement of two or more nominally unrelated domains that form a single heritable unit.
[8] The phosphatase domain belongs to the
auxilin subfamily of lipid phosphatases and is predicted to be catalytically inactive.
[9]
[10]
References
^
a
b
c
GRCh38: Ensembl release 89: ENSG00000116675 –
Ensembl , May 2017
^
a
b
c
GRCm38: Ensembl release 89: ENSMUSG00000028528 –
Ensembl , May 2017
^
"Human PubMed Reference:" . National Center for Biotechnology Information, U.S. National Library of Medicine .
^
"Mouse PubMed Reference:" . National Center for Biotechnology Information, U.S. National Library of Medicine .
^ Seki N, Ohira M, Nagase T, Ishikawa K, Miyajima N, Nakajima D, Nomura N, Ohara O (October 1997).
"Characterization of cDNA clones in size-fractionated cDNA libraries from human brain" . DNA Research . 4 (5): 345–9.
doi :
10.1093/dnares/4.5.345 .
PMID
9455484 .
^ Ohtsuka K, Hata M (April 2000).
"Mammalian HSP40/DNAJ homologs: cloning of novel cDNAs and a proposal for their classification and nomenclature" . Cell Stress & Chaperones . 5 (2): 98–112.
doi :
10.1379/1466-1268(2000)005<0098:mhdhco>2.0.co;2 (inactive 2024-03-12).
PMC
312896 .
PMID
11147971 . {{
cite journal }}
: CS1 maint: DOI inactive as of March 2024 (
link )
^
a
b
"Entrez Gene: DNAJC6 DnaJ (Hsp40) homolog, subfamily C, member 6" .
^ Haynie DT, Xue B (May 2015).
"Superdomains in the protein structure hierarchy: The case of PTP-C2" . Protein Science . 24 (5): 874–82.
doi :
10.1002/pro.2664 .
PMC
4420535 .
PMID
25694109 .
^
"Phosphatase Subfamily Auxilin - PhosphataseWiki" . phosphatome.net .
^ Chen MJ, Dixon JE, Manning G (April 2017). "Genomics and evolution of protein phosphatases". Science Signaling . 10 (474): eaag1796.
doi :
10.1126/scisignal.aag1796 .
PMID
28400531 .
S2CID
41041971 .
External links
Further reading
Suzuki Y, Yamashita R, Shirota M, Sakakibara Y, Chiba J, Mizushima-Sugano J, Nakai K, Sugano S (September 2004).
"Sequence comparison of human and mouse genes reveals a homologous block structure in the promoter regions" . Genome Research . 14 (9): 1711–8.
doi :
10.1101/gr.2435604 .
PMC
515316 .
PMID
15342556 .
Scheele U, Alves J, Frank R, Duwel M, Kalthoff C, Ungewickell E (July 2003).
"Molecular and functional characterization of clathrin- and AP-2-binding determinants within a disordered domain of auxilin" . The Journal of Biological Chemistry . 278 (28): 25357–68.
doi :
10.1074/jbc.M303738200 .
PMID
12732633 .
Scheele U, Kalthoff C, Ungewickell E (September 2001).
"Multiple interactions of auxilin 1 with clathrin and the AP-2 adaptor complex" . The Journal of Biological Chemistry . 276 (39): 36131–8.
doi :
10.1074/jbc.M106511200 .
PMID
11470803 .
Ishikawa K, Nagase T, Nakajima D, Seki N, Ohira M, Miyajima N, Tanaka A, Kotani H, Nomura N, Ohara O (October 1997).
"Prediction of the coding sequences of unidentified human genes. VIII. 78 new cDNA clones from brain which code for large proteins in vitro" . DNA Research . 4 (5): 307–13.
doi :
10.1093/dnares/4.5.307 .
PMID
9455477 .