From Wikipedia, the free encyclopedia
Protein-coding gene in the species Homo sapiens
Heat shock protein 75 kDa, mitochondrial is a
protein that in humans is encoded by the TRAP1
gene .
[5]
[6]
[7]
Interactions
TRAP1 has been shown to
interact with
EXT2 ,
[8]
EXT1
[8] and
Retinoblastoma protein .
[9]
References
^
a
b
c
GRCh38: Ensembl release 89: ENSG00000126602 –
Ensembl , May 2017
^
a
b
c
GRCm38: Ensembl release 89: ENSMUSG00000005981 –
Ensembl , May 2017
^
"Human PubMed Reference:" . National Center for Biotechnology Information, U.S. National Library of Medicine .
^
"Mouse PubMed Reference:" . National Center for Biotechnology Information, U.S. National Library of Medicine .
^ Felts SJ, Owen BA, Nguyen P, Trepel J, Donner DB, Toft DO (March 2000).
"The hsp90-related protein TRAP1 is a mitochondrial protein with distinct functional properties" . J Biol Chem . 275 (5): 3305–12.
doi :
10.1074/jbc.275.5.3305 .
PMID
10652318 .
^ Song HY, Dunbar JD, Zhang YX, Guo D, Donner DB (March 1995).
"Identification of a protein with homology to hsp90 that binds the type 1 tumor necrosis factor receptor" . J Biol Chem . 270 (8): 3574–81.
doi :
10.1074/jbc.270.8.3574 .
PMID
7876093 .
^
"Entrez Gene: TRAP1 TNF receptor-associated protein 1" .
^
a
b Simmons, A D; Musy M M; Lopes C S; Hwang L Y; Yang Y P; Lovett M (November 1999).
"A direct interaction between EXT proteins and glycosyltransferases is defective in hereditary multiple exostoses" . Hum. Mol. Genet . 8 (12): 2155–64.
doi :
10.1093/hmg/8.12.2155 .
ISSN
0964-6906 .
PMID
10545594 .
^ Chen, C F; Chen Y; Dai K; Chen P L; Riley D J; Lee W H (September 1996).
"A new member of the hsp90 family of molecular chaperones interacts with the retinoblastoma protein during mitosis and after heat shock" . Mol. Cell. Biol . 16 (9): 4691–9.
doi :
10.1128/MCB.16.9.4691 .
ISSN
0270-7306 .
PMC
231469 .
PMID
8756626 .
Further reading
Maruyama K, Sugano S (1994). "Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides". Gene . 138 (1–2): 171–4.
doi :
10.1016/0378-1119(94)90802-8 .
PMID
8125298 .
Chen CF, Chen Y, Dai K, et al. (1996).
"A new member of the hsp90 family of molecular chaperones interacts with the retinoblastoma protein during mitosis and after heat shock" . Mol. Cell. Biol . 16 (9): 4691–9.
doi :
10.1128/MCB.16.9.4691 .
PMC
231469 .
PMID
8756626 .
Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K, et al. (1997). "Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library". Gene . 200 (1–2): 149–56.
doi :
10.1016/S0378-1119(97)00411-3 .
PMID
9373149 .
Charng MJ, Zhang D, Kinnunen P, Schneider MD (1998).
"A novel protein distinguishes between quiescent and activated forms of the type I transforming growth factor beta receptor" . J. Biol. Chem . 273 (16): 9365–8.
doi :
10.1074/jbc.273.16.9365 .
PMID
9545258 .
Simmons AD, Musy MM, Lopes CS, et al. (1999).
"A direct interaction between EXT proteins and glycosyltransferases is defective in hereditary multiple exostoses" . Hum. Mol. Genet . 8 (12): 2155–64.
doi :
10.1093/hmg/8.12.2155 .
PMID
10545594 .
Wurthner JU, Frank DB, Felici A, et al. (2001).
"Transforming growth factor-beta receptor-associated protein 1 is a Smad4 chaperone" . J. Biol. Chem . 276 (22): 19495–502.
doi :
10.1074/jbc.M006473200 .
PMID
11278302 .
Strausberg RL, Feingold EA, Grouse LH, et al. (2003).
"Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences" . Proc. Natl. Acad. Sci. U.S.A . 99 (26): 16899–903.
Bibcode :
2002PNAS...9916899M .
doi :
10.1073/pnas.242603899 .
PMC
139241 .
PMID
12477932 .
Ota T, Suzuki Y, Nishikawa T, et al. (2004).
"Complete sequencing and characterization of 21,243 full-length human cDNAs" . Nat. Genet . 36 (1): 40–5.
doi :
10.1038/ng1285 .
PMID
14702039 .
Masuda Y, Shima G, Aiuchi T, et al. (2004).
"Involvement of tumor necrosis factor receptor-associated protein 1 (TRAP1) in apoptosis induced by beta-hydroxyisovalerylshikonin" . J. Biol. Chem . 279 (41): 42503–15.
doi :
10.1074/jbc.M404256200 .
PMID
15292218 .
Gerhard DS, Wagner L, Feingold EA, et al. (2004).
"The Status, Quality, and Expansion of the NIH Full-Length cDNA Project: The Mammalian Gene Collection (MGC)" . Genome Res . 14 (10B): 2121–7.
doi :
10.1101/gr.2596504 .
PMC
528928 .
PMID
15489334 .
Brown V, Brown RA, Ozinsky A, et al. (2006).
"Binding specificity of Toll-like receptor cytoplasmic domains" . Eur. J. Immunol . 36 (3): 742–53.
doi :
10.1002/eji.200535158 .
PMC
2762736 .
PMID
16482509 .
Im CN, Lee JS, Zheng Y, Seo JS (2007). "Iron chelation study in a normal human hepatocyte cell line suggests that tumor necrosis factor receptor-associated protein 1 (TRAP1) regulates production of reactive oxygen species". J. Cell. Biochem . 100 (2): 474–86.
doi :
10.1002/jcb.21064 .
PMID
16927372 .
S2CID
12489077 .
External links