From Wikipedia, the free encyclopedia
Protein-coding gene in the species Homo sapiens
Heat shock 70 kDa protein 4 is a
protein that in humans is encoded by the HSPA4
gene .
[5]
[6]
The
protein encoded by this gene was originally suggested to be a member of the
heat shock protein 70 family.
[5] However it is now known that human HSPA4 is an equivalent to mouse the Apg-2 protein and is a member of the Hsp110 family.
[7]
Interactions
HSPA4 has been shown to
interact with:
References
^
a
b
c
GRCh38: Ensembl release 89: ENSG00000170606 –
Ensembl , May 2017
^
a
b
c
GRCm38: Ensembl release 89: ENSMUSG00000020361 –
Ensembl , May 2017
^
"Human PubMed Reference:" . National Center for Biotechnology Information, U.S. National Library of Medicine .
^
"Mouse PubMed Reference:" . National Center for Biotechnology Information, U.S. National Library of Medicine .
^
a
b Fathallah DM, Cherif D, Dellagi K, Arnaout MA (Jul 1993).
"Molecular cloning of a novel human hsp70 from a B cell line and its assignment to chromosome 5" . Journal of Immunology . 151 (2): 810–3.
doi :
10.4049/jimmunol.151.2.810 .
PMID
8335910 .
^
"Entrez Gene: HSPA4 heat shock 70kDa protein 4" .
^ Kaneko Y, Kimura T, Kishishita M, Noda Y, Fujita J (Apr 1997). "Cloning of apg-2 encoding a novel member of heat shock protein 110 family". Gene . 189 (1): 19–24.
doi :
10.1016/S0378-1119(96)00807-4 .
PMID
9161406 .
^ Saleh A, Srinivasula SM, Balkir L, Robbins PD, Alnemri ES (Aug 2000). "Negative regulation of the Apaf-1 apoptosome by Hsp70". Nature Cell Biology . 2 (8): 476–83.
doi :
10.1038/35019510 .
PMID
10934467 .
S2CID
20374981 .
^
a
b
c Oh WK, Song J (Aug 2003).
"Cooperative interaction of Hsp40 and TPR1 with Hsp70 reverses Hsp70-HspBp1 complex formation" . Molecules and Cells . 16 (1): 84–91.
doi :
10.1016/S1016-8478(23)13770-8 .
PMID
14503850 .
^
a
b Johnson CA, White DA, Lavender JS, O'Neill LP, Turner BM (Mar 2002).
"Human class I histone deacetylase complexes show enhanced catalytic activity in the presence of ATP and co-immunoprecipitate with the ATP-dependent chaperone protein Hsp70" . The Journal of Biological Chemistry . 277 (11): 9590–7.
doi :
10.1074/jbc.M107942200 .
PMID
11777905 .
^ Nair SC, Toran EJ, Rimerman RA, Hjermstad S, Smithgall TE, Smith DF (Dec 1996).
"A pathway of multi-chaperone interactions common to diverse regulatory proteins: estrogen receptor, Fes tyrosine kinase, heat shock transcription factor Hsf1, and the aryl hydrocarbon receptor" . Cell Stress & Chaperones . 1 (4): 237–50.
doi :
10.1379/1466-1268(1996)001<0237:apomci>2.3.co;2 (inactive 2024-04-02).
PMC
376461 .
PMID
9222609 . {{
cite journal }}
: CS1 maint: DOI inactive as of April 2024 (
link )
^ Abravaya K, Myers MP, Murphy SP, Morimoto RI (Jul 1992).
"The human heat shock protein hsp70 interacts with HSF, the transcription factor that regulates heat shock gene expression" . Genes & Development . 6 (7): 1153–64.
doi :
10.1101/gad.6.7.1153 .
PMID
1628823 .
^ Anwar A, Siegel D, Kepa JK, Ross D (Apr 2002).
"Interaction of the molecular chaperone Hsp70 with human NAD(P)H:quinone oxidoreductase 1" . The Journal of Biological Chemistry . 277 (16): 14060–7.
doi :
10.1074/jbc.M111576200 .
PMID
11821413 .
^ Ballinger CA, Connell P, Wu Y, Hu Z, Thompson LJ, Yin LY, Patterson C (Jun 1999).
"Identification of CHIP, a novel tetratricopeptide repeat-containing protein that interacts with heat shock proteins and negatively regulates chaperone functions" . Molecular and Cellular Biology . 19 (6): 4535–45.
doi :
10.1128/mcb.19.6.4535 .
PMC
104411 .
PMID
10330192 .
Further reading
Abravaya K, Myers MP, Murphy SP, Morimoto RI (Jul 1992).
"The human heat shock protein hsp70 interacts with HSF, the transcription factor that regulates heat shock gene expression" . Genes & Development . 6 (7): 1153–64.
doi :
10.1101/gad.6.7.1153 .
PMID
1628823 .
Liao J, Lowthert LA, Ghori N, Omary MB (Jan 1995).
"The 70-kDa heat shock proteins associate with glandular intermediate filaments in an ATP-dependent manner" . The Journal of Biological Chemistry . 270 (2): 915–22.
doi :
10.1074/jbc.270.2.915 .
PMID
7529764 .
Furlini G, Vignoli M, Re MC, Gibellini D, Ramazzotti E, Zauli G, La Placa M (Jan 1994).
"Human immunodeficiency virus type 1 interaction with the membrane of CD4+ cells induces the synthesis and nuclear translocation of 70K heat shock protein" . The Journal of General Virology . 75 (1): 193–9.
doi :
10.1099/0022-1317-75-1-193 .
PMID
7906708 .
Bonaldo MF, Lennon G, Soares MB (Sep 1996).
"Normalization and subtraction: two approaches to facilitate gene discovery" . Genome Research . 6 (9): 791–806.
doi :
10.1101/gr.6.9.791 .
PMID
8889548 .
Schulte AM, Fischer S, Sachse GE, Häfner S, Stelck S, Gassen HG (Mar 1997). "Identification and characterization of a novel hsc70-like gene in the human lung tumor cell line HS24". DNA and Cell Biology . 16 (3): 257–68.
doi :
10.1089/dna.1997.16.257 .
PMID
9115634 .
Kaneko Y, Kimura T, Kishishita M, Noda Y, Fujita J (Apr 1997). "Cloning of apg-2 encoding a novel member of heat shock protein 110 family". Gene . 189 (1): 19–24.
doi :
10.1016/S0378-1119(96)00807-4 .
PMID
9161406 .
Bruner KL, Derfoul A, Robertson NM, Guerriero G, Fernandes-Alnemri T, Alnemri ES, Litwack G (1998). "The unliganded mineralocorticoid receptor is associated with heat shock proteins 70 and 90 and the immunophilin FKBP-52". Receptors & Signal Transduction . 7 (2): 85–98.
PMID
9392437 .
Satyal SH, Chen D, Fox SG, Kramer JM, Morimoto RI (Jul 1998).
"Negative regulation of the heat shock transcriptional response by HSBP1" . Genes & Development . 12 (13): 1962–74.
doi :
10.1101/gad.12.13.1962 .
PMC
316975 .
PMID
9649501 .
Naylor DJ, Stines AP, Hoogenraad NJ, Høj PB (Aug 1998).
"Evidence for the existence of distinct mammalian cytosolic, microsomal, and two mitochondrial GrpE-like proteins, the Co-chaperones of specific Hsp70 members" . The Journal of Biological Chemistry . 273 (33): 21169–77.
doi :
10.1074/jbc.273.33.21169 .
PMID
9694873 .
Melville MW, Tan SL, Wambach M, Song J, Morimoto RI, Katze MG (Feb 1999).
"The cellular inhibitor of the PKR protein kinase, P58(IPK), is an influenza virus-activated co-chaperone that modulates heat shock protein 70 activity" . The Journal of Biological Chemistry . 274 (6): 3797–803.
doi :
10.1074/jbc.274.6.3797 .
PMID
9920933 .
Ballinger CA, Connell P, Wu Y, Hu Z, Thompson LJ, Yin LY, Patterson C (Jun 1999).
"Identification of CHIP, a novel tetratricopeptide repeat-containing protein that interacts with heat shock proteins and negatively regulates chaperone functions" . Molecular and Cellular Biology . 19 (6): 4535–45.
doi :
10.1128/mcb.19.6.4535 .
PMC
104411 .
PMID
10330192 .
Liu H, Vuyyuru VB, Pham CD, Yang Y, Singh B (Jun 1999).
"Evidence of an interaction between Mos and Hsp70: a role of the Mos residue serine 3 in mediating Hsp70 association" . Oncogene . 18 (23): 3461–70.
doi :
10.1038/sj.onc.1202699 .
PMID
10376524 .
Nonoguchi K, Itoh K, Xue JH, Tokuchi H, Nishiyama H, Kaneko Y, Tatsumi K, Okuno H, Tomiwa K, Fujita J (Sep 1999). "Cloning of human cDNAs for Apg-1 and Apg-2, members of the Hsp110 family, and chromosomal assignment of their genes". Gene . 237 (1): 21–8.
doi :
10.1016/S0378-1119(99)00325-X .
PMID
10524232 .
O'Keeffe B, Fong Y, Chen D, Zhou S, Zhou Q (Jan 2000).
"Requirement for a kinase-specific chaperone pathway in the production of a Cdk9/cyclin T1 heterodimer responsible for P-TEFb-mediated tat stimulation of HIV-1 transcription" . The Journal of Biological Chemistry . 275 (1): 279–87.
doi :
10.1074/jbc.275.1.279 .
PMID
10617616 .
Agostini I, Popov S, Li J, Dubrovsky L, Hao T, Bukrinsky M (Sep 2000). "Heat-shock protein 70 can replace viral protein R of HIV-1 during nuclear import of the viral preintegration complex". Experimental Cell Research . 259 (2): 398–403.
doi :
10.1006/excr.2000.4992 .
PMID
10964507 .
Kim M, Jiang LH, Wilson HL, North RA, Surprenant A (Nov 2001).
"Proteomic and functional evidence for a P2X7 receptor signalling complex" . The EMBO Journal . 20 (22): 6347–58.
doi :
10.1093/emboj/20.22.6347 .
PMC
125721 .
PMID
11707406 .
Johnson CA, White DA, Lavender JS, O'Neill LP, Turner BM (Mar 2002).
"Human class I histone deacetylase complexes show enhanced catalytic activity in the presence of ATP and co-immunoprecipitate with the ATP-dependent chaperone protein Hsp70" . The Journal of Biological Chemistry . 277 (11): 9590–7.
doi :
10.1074/jbc.M107942200 .
PMID
11777905 .
Gurer C, Cimarelli A, Luban J (May 2002).
"Specific incorporation of heat shock protein 70 family members into primate lentiviral virions" . Journal of Virology . 76 (9): 4666–70.
doi :
10.1128/JVI.76.9.4666-4670.2002 .
PMC
155079 .
PMID
11932435 .
Freeman BC, Yamamoto KR (Jun 2002). "Disassembly of transcriptional regulatory complexes by molecular chaperones". Science . 296 (5576): 2232–5.
doi :
10.1126/science.1073051 .
PMID
12077419 .
S2CID
8844179 .
External links