Ubiquitin-conjugating enzyme E2 H is a
protein that in humans is encoded by the UBE2Hgene.[5][6]
The modification of proteins with
ubiquitin is an important cellular mechanism for targeting abnormal or short-lived proteins for degradation.
Ubiquitination involves at least three classes of
enzymes: ubiquitin-activating enzymes, or E1s, ubiquitin-conjugating enzymes, or E2s, and
ubiquitin-protein ligases, or E3s. This gene encodes a member of the E2 ubiquitin-conjugating enzyme family. The encoded
protein sequence is 100% identical to the mouse
homolog and 98% identical to the frog and zebrafish homologs. Two alternatively spliced transcript variants have been found for this gene and they encode distinct
isoforms.[6]
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