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BHFF
Identifiers
  • 5,7-Bis(1,1-dimethylethyl)-3-hydroxy-3(trifluoromethyl)-2(3H)-benzofuranone
CAS Number
PubChem CID
ChemSpider
UNII
CompTox Dashboard ( EPA)
ECHA InfoCard 100.229.838 Edit this at Wikidata
Chemical and physical data
FormulaC17H21F3O3
Molar mass330.347 g·mol−1
3D model ( JSmol)
  • FC(F)(F)C2(O)c1cc(C(C)(C)C)cc(C(C)(C)C)c1OC2=O
  • InChI=1S/C17H21F3O3/c1-14(2,3)9-7-10(15(4,5)6)12-11(8-9)16(22,13(21)23-12)17(18,19)20/h7-8,22H,1-6H3 checkY
  • Key:RVNOANDLZIIFHB-UHFFFAOYSA-N checkY
   (verify)

BHFF is a compound used in scientific research which acts as a positive allosteric modulator at the GABAB receptor. It has anxiolytic effects in animal studies, and good oral bioavailability. [1]

References

  1. ^ Malherbe P, Masciadri R, Norcross RD, Knoflach F, Kratzeisen C, Zenner MT, et al. (June 2008). "Characterization of (R,S)-5,7-di-tert-butyl-3-hydroxy-3-trifluoromethyl-3H-benzofuran-2-one as a positive allosteric modulator of GABAB receptors". British Journal of Pharmacology. 154 (4): 797–811. doi: 10.1038/bjp.2008.135. PMC  2439845. PMID  18536733.

External links

  • Media related to BHFF at Wikimedia Commons
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