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Drug class
An androgen synthesis inhibitor is a type of drug which
inhibits the
enzymatic
synthesis of
androgens, such as
testosterone and
dihydrotestosterone (DHT).
[1] They include:
Inhibitors of cholesterol synthesis can also reduce androgen production by inhibiting cholesterol production.
Androgen synthesis inhibitors have medical applications in the treatment of
benign prostatic hypertrophy,
prostate cancer,
[1]
androgenetic alopecia,
hirsutism,
precocious puberty, and
hyperandrogenism, among other
androgen-dependent conditions.
Because androgens are the
endogenous
precursors of
estrogens, androgen synthesis inhibitors also function as
estrogen synthesis inhibitors and can reduce estrogen production and levels.
See also
References
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Androgens (incl.
AASTooltip anabolic–androgenic steroid) | |
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Antiandrogens |
ARTooltip Androgen receptor
antagonists | |
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Steroidogenesis inhibitors | |
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Antigonadotropins |
-
D2 receptor
antagonists (
prolactin releasers) (e.g.,
domperidone,
metoclopramide,
risperidone,
haloperidol,
chlorpromazine,
sulpiride)
-
Estrogens (e.g.,
bifluranol,
diethylstilbestrol,
estradiol,
estradiol esters,
ethinylestradiol,
ethinylestradiol sulfonate,
paroxypropione)
-
GnRH agonists (e.g.,
leuprorelin)
-
GnRH antagonists (e.g.,
cetrorelix)
-
Progestogens (incl.,
chlormadinone acetate,
cyproterone acetate,
hydroxyprogesterone caproate,
gestonorone caproate,
medroxyprogesterone acetate,
megestrol acetate)
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Others | |
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