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A matrix metalloproteinase inhibitor ( INN stem –mastat [1]) inhibits matrix metalloproteinases. Because they inhibit cell migration, they have antiangiogenic effects. They are endogenous or exogenous.
The most notorious endogenous metalloproteinases are tissue inhibitors of metalloproteinases, followed by cartilage-derived angiogenesis inhibitors.
Exogenous matrix metalloproteinase inhibitors were developed as anticancer drugs. [2] Examples include:
Metalloproteinase inhibitors are found in numerous marine organisms, including fish, cephalopods, mollusks, algae and bacteria. [3]
See also
References
- ^ "The Use of Stems in the Selection of International Nonproprietary Names (INN) for Pharmaceutical Substances" (PDF). World Health Organization. Retrieved 5 November 2016.
- ^ Coussens, L. M. (2002). "Matrix Metalloproteinase Inhibitors and Cancer--Trials and Tribulations". Science. 295 (5564): 2387–2392. Bibcode: 2002Sci...295.2387C. doi: 10.1126/science.1067100. ISSN 0036-8075. PMID 11923519. S2CID 19944201.
- ^ Noel Vinay Thomas; Se Kwon Kim (2010). "Metalloproteinase Inhibitors Stts and Scope from Marine Organisms". Biochemistry Research International. 2010: 845975. doi: 10.1155/2010/845975. PMC 3004377. PMID 21197102.
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