From Wikipedia, the free encyclopedia
Adenosine

An adenosine reuptake inhibitor (AdoRI) is a type of drug which acts as a reuptake inhibitor for the purine nucleoside and neurotransmitter adenosine by blocking the action of one or more of the equilibrative nucleoside transporters (ENTs). [1] [2] [3] This in turn leads to increased extracellular concentrations of adenosine and therefore an increase in adenosinergic neurotransmission.

Main article: Reuptake inhibitor

List of AdoRIs

See also

References

  1. ^ a b c d SenGupta DJ, Unadkat JD (2004). "Glycine 154 of the equilibrative nucleoside transporter, hENT1, is important for nucleoside transport and for conferring sensitivity to the inhibitors nitrobenzylthioinosine, dipyridamole, and dilazep". Biochem Pharmacol. 67 (3): 453–458. doi: 10.1016/j.bcp.2003.09.018. PMID  15037197.
  2. ^ Endres CJ, Sengupta DJ, Unadkat JD (2004). "Mutation of leucine-92 selectively reduces the apparent affinity of inosine, guanosine, NBMPR [S6-(4-nitrobenzyl)-mercaptopurine riboside] and dilazep for the human equilibrative nucleoside transporter, hENT1". Biochem J. 380 (1): 131–137. doi: 10.1042/BJ20031880. PMC  1224139. PMID  14759222.
  3. ^ Chaudary N, Naydenova Z, Shuralyova I, Coe IR (2004). "The adenosine transporter, mENT1, is a target for adenosine receptor signaling and protein kinase Cepsilon in hypoxic and pharmacological preconditioning in the mouse cardiomyocyte cell line, HL-1". J Pharmacol Exp Ther. 310 (3): 1190–1198. doi: 10.1124/jpet.104.067157. PMID  15131243. S2CID  21804556.
  4. ^ a b c d e f Goldfrank LR, Neal Flomenbaum, Mary Ann Howland, Robert S. (2006). Goldfrank's toxicologic emergencies. p.  243.
  5. ^ a b c Narimatsu E, Niiya T, Kawamata M, Namiki A (2006). "[The mechanisms of depression by benzodiazepines, barbiturates and propofol of excitatory synaptic transmissions mediated by adenosine neuromodulation]". Masui. 55 (6): 684–691. PMID  16780077.
  6. ^ Tohdoh Y, Narimatsu E, Kawamata M, Namiki A (2000). "The involvement of adenosine neuromodulation in pentobarbital-induced field excitatory postsynaptic potentials depression in rat hippocampal slices". Anesth Analg. 91 (6): 1537–1541. doi: 10.1097/00000539-200012000-00044. PMID  11094014.
  7. ^ Patel J, Marangos PJ, Skolnick P, Paul SM, Martino AM (1982). "Benzodiazepines are weak inhibitors of [3H]nitrobenzylthioinosine binding to adenosine uptake sites in brain". Neurosci Lett. 29 (1): 79–82. doi: 10.1016/0304-3940(82)90368-8. PMID  7070715. S2CID  39089007.
  8. ^ York MJ, Davies LP (1982). "The effect of diazepam on adenosine uptake and adenosine-stimulated adenylate cyclase in guinea-pig brain". Can J Physiol Pharmacol. 60 (3): 302–307. doi: 10.1139/y82-041. PMID  6280826.
  9. ^ Ujfalusi A, Cseppentö A, Nagy E, Szabó JZ, Kovács P, Szentmiklósi AJ (1999). "Sensitization by chronic diazepam treatment of A2A adenosine receptor-mediated relaxation in rat pulmonary artery". Life Sci. 64 (2): PL19–25. doi: 10.1016/S0024-3205(98)00547-5. PMID  10069495.
  10. ^ Narimatsu E, Niiya T, Kawamata M, Namiki A (2008). "Adenosine and adenosine uptake inhibitors potentiate the neuromuscular blocking action of rocuronium mediated by adenosine A(1) receptors in isolated rat diaphragms". Acta Anaesthesiol Scand. 52 (10): 1415–1422. doi: 10.1111/j.1399-6576.2008.01714.x. PMID  19025536. S2CID  21837865.
  11. ^ Bender AS, Hertz L (1986). "Similarities of adenosine uptake systems in astrocytes and neurons in primary cultures". Neurochem Res. 11 (11): 1507–1524. doi: 10.1007/BF00965770. PMID  2891057. S2CID  8585637.
  12. ^ O'Regan MH, Phillis JW (1988). "Potentiation of adenosine-evoked depression of rat cerebral cortical neurons by triazolam". Brain Res. 445 (2): 376–379. doi: 10.1016/0006-8993(88)91203-6. PMID  3370471. S2CID  33550022.
  13. ^ a b Phillis JW, Delong RE (1984). "A purinergic component in the central actions of meprobamate". Eur J Pharmacol. 101 (3–4): 295–297. doi: 10.1016/0014-2999(84)90174-2. PMID  6468504.
  14. ^ a b DeLong RE, Phillis JW, Barraco RA (1985). "A possible role of endogenous adenosine in the sedative action of meprobamate". Eur J Pharmacol. 118 (3): 359–362. doi: 10.1016/0014-2999(85)90149-9. PMID  4085561.
  15. ^ Gonzalez LA, Gatch MB, Taylor CM, Bell-Horner CL, Forster MJ, Dillon GH (2009). "[Carisoprodol-mediated modulation of GABAA receptors: in vitro and in vivo studies". J Pharmacol Exp Ther. 329 (2): 827–837. doi: 10.1124/jpet.109.151142. PMC  2672873. PMID  19244096.
  16. ^ Wang S, Cone J, Fong M, Yoshitake M, Kambayashi Ji, Liu Y (2001). "Interplay between inhibition of adenosine uptake and phosphodiesterase type 3 on cardiac function by cilostazol, an agent to treat intermittent claudication". J Cardiovasc Pharmacol. 38 (5): 775–783. doi: 10.1097/00005344-200111000-00014. PMID  11602824.
  17. ^ a b c d e Phillis JW, Wu PH (1982). "The effect of various centrally active drugs on adenosine uptake by the central nervous system". Comp Biochem Physiol C. 72 (2): 179–187. doi: 10.1016/0306-4492(82)90082-X. PMID  6128137.
  18. ^ a b Phillis J.W. (1984). "Potentiation of the action of adenosine on cerebral cortical neurones by the tricyclic antidepressants". Br J Pharmacol. 83 (2): 567–575. doi: 10.1111/j.1476-5381.1984.tb16521.x. PMC  1987110. PMID  6487906.
  19. ^ Stein MB, Black B, Brown TM, Uhde TW (1993). "Lack of efficacy of the adenosine reuptake inhibitor dipyridamole in the treatment of anxiety disorders". Biol Psychiatry. 33 (8–9): 647–650. doi: 10.1016/0006-3223(93)90105-M. PMID  8329495. S2CID  54364716.
  20. ^ a b Phillis JW, Bender AS, Marszalec W (1985). "Estradiol and progesterone potentiate adenosine's depressant action on rat cerebral cortical neurons". Gen Pharmacol. 16 (6): 609–612. doi: 10.1016/0306-3623(85)90151-x. PMID  2935451.
  21. ^ Allen-Gipson DS, Jarrell JC, Bailey KL, Robinson JE, Kharbanda KK, Sisson JH, Wyatt TA (2009). "Ethanol Blocks Adenosine Uptake via Inhibiting the Nucleoside Transport System in Bronchial Epithelial Cells". Alcohol Clin Exp Res. 33 (5): 791–8. doi: 10.1111/j.1530-0277.2009.00897.x. PMC  2940831. PMID  19298329.
  22. ^ Verma A, Houston M, Marangos PJ (1985). "Solubilization of an adenosine uptake site in brain". J Neurochem. 45 (2): 596–603. doi: 10.1111/j.1471-4159.1985.tb04028.x. PMID  2989430. S2CID  42431981.
  23. ^ a b Phillis JW, Wu PH, Coffin VL (1983). "Inhibition of adenosine uptake into rat brain synaptosomes by prostaglandins, benzodiazepines and other centrally active compounds". Gen Pharmacol. 14 (5): 475–479. doi: 10.1016/0306-3623(83)90106-4. PMID  6416920.
  24. ^ Ngai AC, Monsen MR, Ibayashi S, Ko KR, Winn HR (1989). "Effect of inosine on pial arterioles: potentiation of adenosine-induced vasodilation". Am J Physiol. 256 (3 (Pt2)): H603–H606. doi: 10.1152/ajpheart.1989.256.3.H603. PMID  2923227.
  25. ^ Noji T, Nan-ya K, Mizutani M, Katagiri C, Sano J, Takada C, Nishikawa S, Karasawa A, Kusaka H (2002). "KF24345, an adenosine uptake inhibitor, ameliorates the severity and mortality of lethal acute pancreatitis via endogenous adenosine in mice". Eur J Pharmacol. 454 (1): 85–93. doi: 10.1016/S0014-2999(02)02476-7. PMID  12409009.
  26. ^ Lee CM, Cheung WT (1985). "Inhibitory effect of adenosine on electrically evoked contractions in the rat vas deferens: pharmacological characterization". Neurosci Lett. 59 (1): 47–52. doi: 10.1016/0304-3940(85)90213-7. PMID  2995881. S2CID  42019444.
  27. ^ Marangos PJ, Patel J, Clark-Rosenberg R, Martino AM (1982). "[3H]nitrobenzylthioinosine binding as a probe for the study of adenosine uptake sites in brain". J. Neurochem. 39 (1): 184–191. doi: 10.1111/j.1471-4159.1982.tb04717.x. PMID  7086410. S2CID  25920625.
  28. ^ Coffin VL, Taylor JA, Phillis JW, Altman HJ, Barraco RA (1984). "Behavioral interaction of adenosine and methylxanthines on central purinergic systems". Neurosci Lett. 47 (2): 91–98. doi: 10.1016/0304-3940(84)90412-9. PMID  6205333. S2CID  19628381.
  29. ^ Shi D, Daly JW (1999). "Chronic effects of xanthines on levels of central receptors in mice". Cell Mol Neurobiol. 19 (6): 719–732. doi: 10.1023/A:1006901005925. PMID  10456233. S2CID  10644334.
  30. ^ Phillis J.W. (1985). "Chlorpromazine and trifluoperazine potentiate the action of adenosine on rat cerebral cortical neurons". Gen Pharmacol. 16 (1): 19–24. doi: 10.1016/0306-3623(85)90264-2. PMID  2984085.
  31. ^ Phillis J.W. (1984). "Interactions of the anticonvulsants diphenylhydantoin and carbamazepine with adenosine on cerebral cortical neurons". Epilepsia. 25 (6): 765–772. doi: 10.1111/j.1528-1157.1984.tb03489.x. PMID  6510384. S2CID  30358234.
  32. ^ Andiné P, Rudolphi KA, Fredholm BB, Hagberg H (1990). "Effect of propentofylline (HWA 285) on extracellular purines and excitatory amino acids in CA1 of rat hippocampus during transient ischaemia". Br J Pharmacol. 100 (4): 814–818. doi: 10.1111/j.1476-5381.1990.tb14097.x. PMC  1917600. PMID  2207501.
  33. ^ Ohmori H, Sato Y, Namiki A (2004). "The anticonvulsant action of propofol on epileptiform activity in rat hippocampal slices". Anesth Analg. 99 (4): 1095–1101. doi: 10.1213/01.ANE.0000130356.22414.2B. PMID  15385357.
  34. ^ Noji T, Nan-ya K, Katagiri C, Mizutani M, Sano J, Nishikawa S, Karasawa A, Kusaka H (2002). "Adenosine uptake inhibition ameliorates cerulein-induced acute pancreatitis in mice". Pancreas. 25 (4): 387–392. doi: 10.1097/00006676-200211000-00011. PMID  12409834. S2CID  24260175.
  35. ^ Gresele P, Arnout J, Deckmyn H, Vermylen J (1986). "Mechanism of the antiplatelet action of dipyridamole in whole blood: modulation of adenosine concentration and activity". Thromb Haemost. 55 (1): 12–18. doi: 10.1055/s-0038-1661437. PMID  3704998. S2CID  7318055.
  36. ^ Bauman LA, Mahle CD, Boissard CG, Gribkoff VK (1992). "Age-dependence of effects of A1 adenosine receptor antagonism in rat hippocampal slices". J Neurophysiol. 68 (2): 629–638. doi: 10.1152/jn.1992.68.2.629. PMID  1388201.
  37. ^ Boissard CG, Gribkoff VK (1993). "The effects of the adenosine reuptake inhibitor soluflazine on synaptic potentials and population hypoxic depolarizations in area CA1 of rat hippocampus in vitro". Neuropharmacology. 32 (2): 149–155. doi: 10.1016/0028-3908(93)90095-K. PMID  8383814. S2CID  10716297.
Retrieved from " https://en.wikipedia.org/?title=Adenosine_reuptake_inhibitor&oldid=1213032636"