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Silicone granuloma
Snowball like hyperechogenic axillary lymph nodes in a woman with silicone implants removed due to complications
SpecialtyDermatology

Silicone granulomas are a skin condition that occur as a reaction to liquid silicones, and are characterized by the formation of nodules. [1]: 46 

Formation of a granuloma is a common tissue response to a range of foreign bodies. Silicone can be directly injected into tissue as part of a cosmetic procedure or it can leak from silicone implants. The formation and consequences of silicon-induced granulomas is not well described or understood. The extent of damage that they cause is controversial. [2]

Localization

Effects

Silicone-induced granuloma can be associated with fever, [12] calcitriol-mediated hypercalcemia, [13] reactive amyloidosis. [14] [15] [16]

Treatment

Treatment of silicone granulomas and removal of unwanted silicone have historically been very challenging. Anti-inflammatory agents (e.g., oral corticosteroids, allopurinol, colchicine, isotretinoin, cyclosporine, imiquimod, antibiotics) may help treat the granulomatous inflammation, [17] but do not address or remove the underlying source silicone material. Surgical excision allows for removal of the underlying source of inflammation, but is often deferred due to associated scarring. [18]

More recently, a case of successful removal of injected silicone using microcoring technology was reported, providing a potential scar-less option for its removal. [18]

Gallery

See also

References

  1. ^ James, William D.; Berger, Timothy G.; et al. (2006). Andrews' Diseases of the Skin: clinical Dermatology. Saunders Elsevier. ISBN  978-0-7216-2921-6.
  2. ^ Ellis, L. Z.; Cohen, J. L.; High, W (2012). "Granulomatous reaction to silicone injection". The Journal of Clinical and Aesthetic Dermatology. 5 (7): 44–7. PMC  3396457. PMID  22798975.
  3. ^ Péoc'h, M; Duprez, D; Grice, G; Fabre-Bocquentin, B; Gressin, R; Pasquier, B (2000). "Silicone lymphadenopathy mimicking a lymphoma in a patient with a metatarsophalangeal joint prosthesis". Journal of Clinical Pathology. 53 (7): 549–51. doi: 10.1136/jcp.53.7.549. PMC  1731232. PMID  10961180.
  4. ^ García Callejo, F. J.; Calvo González, J; Agustí Martínez, J; Bécares Martínez, C; Monzó Gandía, R; Marco Algarra, J (2013). "Neck lymphadenitis due to silicone granuloma after mammary implants". Acta Otorrinolaringológica Española. 64 (3): 217–22. doi: 10.1016/j.otorri.2012.12.003. PMID  23499209.
  5. ^ Rieder, E; Desai, S; Mundi, J. P.; Boyd, K. P.; Patel, R. R.; Ramachandran, S; Franks Jr, A. G. (2013). "Granulomatous dermatitis related to silicone implant". Dermatology Online Journal. 19 (12): 20708. doi: 10.5070/D31912020708. PMID  24364999.
  6. ^ El-Charnoubi, W. A.; Foged Henriksen, T; Joergen Elberg, J (2011). "Cutaneous silicone granuloma mimicking breast cancer after ruptured breast implant". Case Reports in Dermatological Medicine. 2011: 1–3. doi: 10.1155/2011/129138. PMC  3505939. PMID  23198167.
  7. ^ Schwartzfarb, E. M.; Hametti, J. M.; Romanelli, P; Ricotti, C (2008). "Foreign body granuloma formation secondary to silicone injection". Dermatology Online Journal. 14 (7): 20. doi: 10.5070/D37JX780XV. PMID  18718204.
  8. ^ Inn, F. X.; Imran, F. H.; Ali, M. F.; Ih, R; z, Z (2012). "Penile augmentation with resultant foreign material granuloma and sequalae". The Malaysian Journal of Medical Sciences. 19 (4): 81–3. PMC  3629684. PMID  23613653.
  9. ^ El-Charnoubi, W. A.; Foged Henriksen, T; Joergen Elberg, J (2011). "Cutaneous silicone granuloma mimicking breast cancer after ruptured breast implant". Case Reports in Dermatological Medicine. 2011: 1–3. doi: 10.1155/2011/129138. PMC  3505939. PMID  23198167.
  10. ^ Symmers, W. S. (1968). "Silicone mastitis in "topless" waitresses and some other varieties of foreign-body mastitis". British Medical Journal. 3 (5609): 19–22. doi: 10.1136/bmj.3.5609.8-a. PMC  1989508. PMID  5690841.
  11. ^ Poveda, R; Bagán, J. V.; Murillo, J; Jiménez, Y (2006). "Granulomatous facial reaction to injected cosmetic fillers--a presentation of five cases". Medicina Oral, Patologia Oral y Cirugia Bucal. 11 (1): E1–5. PMID  16388285.
  12. ^ Blum, A; Abboud, W; Shajrawi, I; Tatour, I (2007). "Prolonged fever due to silicone granulomatosis". The Israel Medical Association Journal. 9 (2): 121–2. PMID  17348488.
  13. ^ Agrawal, N; Altiner, S; Mezitis, N. H.; Helbig, S (2013). "Silicone-induced granuloma after injection for cosmetic purposes: A rare entity of calcitriol-mediated hypercalcemia". Case Reports in Medicine. 2013: 1–3. doi: 10.1155/2013/807292. PMC  3864076. PMID  24363673.
  14. ^ d'Ythurbide, G; Kerrou, K; Brocheriou, I; Hertig, A (2012). "Reactive amyloidosis complicated by end-stage renal disease 28 years after liquid silicone injection in the buttocks". BMJ Case Reports. 2012: bcr2012006803. doi: 10.1136/bcr-2012-006803. PMC  4543521. PMID  23035166.
  15. ^ Emekli, U; Tümerdem, B; Demiryont, M (2002). "Rupture of a silicone gel mammary prosthesis and amyloidosis: A case report". Aesthetic Plastic Surgery. 26 (5): 383–7. doi: 10.1007/s00266-002-2022-x. PMID  12432480. S2CID  6865930.
  16. ^ Goldman, A. B.; Bansal, M (1996). "Amyloidosis and silicone synovitis: Updated classification, updated pathophysiology, and synovial articular abnormalities". Radiologic Clinics of North America. 34 (2): 375–94, xi. doi: 10.1016/S0033-8389(22)00474-2. PMID  8633122. S2CID  251523786.
  17. ^ Pérez-Ruiz, Carmen; Barabash-Neila, Román; Zulueta-Dorado, Teresa; Conejo-Mir Sánchez, Julián (March 2019). "Adverse Granulomatous Reaction to Silicone Filler Treated With Methotrexate". Dermatologic Surgery. 45 (3): 489–492. doi: 10.1097/DSS.0000000000001574. ISSN  1076-0512.
  18. ^ a b Hashemi, David A.; Tao, Joy; Wang, Jordan V.; Geronemus, Roy G. (2024-01-04). "Injected Silicone Removed Using Dermal Microcoring". Dermatologic Surgery. doi: 10.1097/DSS.0000000000004068. ISSN  1076-0512.


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