Warty dyskeratoma, also known as an Isolated dyskeratosis follicularis,[1]: 777 is a
benign[2]epidermal proliferation with distinctive histologic findings that may mimic invasive squamous cell carcinoma[3] and commonly manifests as an umbilicated (Having a central mark or depression resembling a
navel) lesion with a
keratotic plug,[4] WD have some histopathologic similarities to
viral warts but it's not caused by
HPV and the majority of these lesions display overall histopathologic features consistent with a
follicular adnexal neoplasm.[5] Usually limited to the
head,
neck,[6]scalp[7] or
face and
vulva.[6] Lesions are generally
solitary and sporadic and may be associated with a
follicular unit.
Oral involvement,[4] particularly the
hard palate, and
genital involvement have been reported. it can also be thought of as one of the manifestations of focal
acantholyticdyskeratosis, an epidermal reaction pattern that can be seen in several disorders, including
Darier's disease and
Grover's disease.[8]: 639 But the main Difference between Darier disease and Warty dyskeratoma, is that Darier disease inherited
dermatosis (
autosomal dominant) consisting of multiple keratotic
papules on the
face,
trunk, and
extremities, while WD occurs as an isolated, noninherited, single keratotic nodule mainly confined to the
head and
neck as mentioned earlier.[6]