From Wikipedia, the free encyclopedia
Protein-coding gene in the species Homo sapiens
Proton-coupled amino acid transporter 1 is a
protein that in humans is encoded by the SLC36A1
gene .
[5]
[6]
[7]
This gene encodes a member of the eukaryote-specific
amino acid/auxin permease (AAAP) 1 transporter family. The encoded protein functions as a proton-dependent, small amino acid transporter. This gene is clustered with related family members on chromosome 5q33.1.
[7]
See also
References
^
a
b
c
GRCh38: Ensembl release 89: ENSG00000123643 –
Ensembl , May 2017
^
a
b
c
GRCm38: Ensembl release 89: ENSMUSG00000020261 –
Ensembl , May 2017
^
"Human PubMed Reference:" . National Center for Biotechnology Information, U.S. National Library of Medicine .
^
"Mouse PubMed Reference:" . National Center for Biotechnology Information, U.S. National Library of Medicine .
^ Boll M, Foltz M, Rubio-Aliaga I, Kottra G, Daniel H (Jun 2002).
"Functional characterization of two novel mammalian electrogenic proton-dependent amino acid cotransporters" . J Biol Chem . 277 (25): 22966–73.
doi :
10.1074/jbc.M200374200 .
PMID
11959859 .
^ Sagne C, Agulhon C, Ravassard P, Darmon M, Hamon M, El Mestikawy S, Gasnier B, Giros B (Jun 2001).
"Identification and characterization of a lysosomal transporter for small neutral amino acids" . Proc Natl Acad Sci U S A . 98 (13): 7206–11.
Bibcode :
2001PNAS...98.7206S .
doi :
10.1073/pnas.121183498 .
PMC
34647 .
PMID
11390972 .
^
a
b
"Entrez Gene: SLC36A1 solute carrier family 36 (proton/amino acid symporter), member 1" .
Further reading
Hartley JL, Temple GF, Brasch MA (2001).
"DNA Cloning Using In Vitro Site-Specific Recombination" . Genome Res . 10 (11): 1788–95.
doi :
10.1101/gr.143000 .
PMC
310948 .
PMID
11076863 .
Wiemann S, Weil B, Wellenreuther R, et al. (2001).
"Toward a Catalog of Human Genes and Proteins: Sequencing and Analysis of 500 Novel Complete Protein Coding Human cDNAs" . Genome Res . 11 (3): 422–35.
doi :
10.1101/gr.GR1547R .
PMC
311072 .
PMID
11230166 .
Simpson JC, Wellenreuther R, Poustka A, et al. (2001).
"Systematic subcellular localization of novel proteins identified by large-scale cDNA sequencing" . EMBO Rep . 1 (3): 287–92.
doi :
10.1093/embo-reports/kvd058 .
PMC
1083732 .
PMID
11256614 .
Chen Z, Fei YJ, Anderson CM, et al. (2003).
"Structure, function and immunolocalization of a proton-coupled amino acid transporter (hPAT1) in the human intestinal cell line Caco-2" . J. Physiol . 546 (Pt 2): 349–61.
doi :
10.1113/jphysiol.2002.026500 .
PMC
2342508 .
PMID
12527723 .
Wreden CC, Johnson J, Tran C, et al. (2003).
"The H+-coupled electrogenic lysosomal amino acid transporter LYAAT1 localizes to the axon and plasma membrane of hippocampal neurons" . J. Neurosci . 23 (4): 1265–75.
doi :
10.1523/JNEUROSCI.23-04-01265.2003 .
PMC
6742289 .
PMID
12598615 .
Boll M, Foltz M, Rubio-Aliaga I, Daniel H (2004). "A cluster of proton/amino acid transporter genes in the human and mouse genomes". Genomics . 82 (1): 47–56.
doi :
10.1016/S0888-7543(03)00099-5 .
PMID
12809675 .
Ota T, Suzuki Y, Nishikawa T, et al. (2004).
"Complete sequencing and characterization of 21,243 full-length human cDNAs" . Nat. Genet . 36 (1): 40–5.
doi :
10.1038/ng1285 .
PMID
14702039 .
Bermingham JR, Pennington J (2004). "Organization and expression of the SLC36 cluster of amino acid transporter genes". Mamm. Genome . 15 (2): 114–25.
doi :
10.1007/s00335-003-2319-3 .
PMID
15058382 .
S2CID
21418124 .
Wiemann S, Arlt D, Huber W, et al. (2004).
"From ORFeome to Biology: A Functional Genomics Pipeline" . Genome Res . 14 (10B): 2136–44.
doi :
10.1101/gr.2576704 .
PMC
528930 .
PMID
15489336 .
Anderson CM, Grenade DS, Boll M, et al. (2004).
"H+/amino acid transporter 1 (PAT1) is the imino acid carrier: An intestinal nutrient/drug transporter in human and rat" . Gastroenterology . 127 (5): 1410–22.
doi :
10.1053/j.gastro.2004.08.017 .
PMID
15521011 .
Anderson CM, Thwaites DT (2005). "Indirect regulation of the intestinal H+-coupled amino acid transporter hPAT1 (SLC36A1)". J. Cell. Physiol . 204 (2): 604–13.
doi :
10.1002/jcp.20337 .
PMID
15754324 .
S2CID
31443973 .
Abbot EL, Grenade DS, Kennedy DJ, et al. (2006).
"Vigabatrin transport across the human intestinal epithelial (Caco-2) brush-border membrane is via the H+-coupled amino-acid transporter hPAT1" . Br. J. Pharmacol . 147 (3): 298–306.
doi :
10.1038/sj.bjp.0706557 .
PMC
1751303 .
PMID
16331283 .
Mehrle A, Rosenfelder H, Schupp I, et al. (2006).
"The LIFEdb database in 2006" . Nucleic Acids Res . 34 (Database issue): D415–8.
doi :
10.1093/nar/gkj139 .
PMC
1347501 .
PMID
16381901 .
Kuan YH, Gruebl T, Soba P, et al. (2007).
"PAT1a modulates intracellular transport and processing of amyloid precursor protein (APP), APLP1, and APLP2" . J. Biol. Chem . 281 (52): 40114–23.
doi :
10.1074/jbc.M605407200 .
PMID
17050537 .
This article incorporates text from the
United States National Library of Medicine , which is in the
public domain .
By group
SLC1–10
(1): (2): (3): (4): (5): (6): (7): (8): (9): (10):
SLC11–20
(11): (12): (13): (14): (15): (16): (17): (18): (19): (20):
SLC21–30
(21): (22): (23): (24): (25): (26): (27): (28): (29): (30):
SLC31–40
(31): (32): (33): (34): (35): (36): (37): (38): (39): (40):
SLC41–48
(41): (42): (43): (44): (45): (46): (47): (48):