| Amino Acid/Auxin Permease Family | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Identifiers | |||||||||
| Symbol | AAAP | ||||||||
| Pfam | PF01490 | ||||||||
| Pfam clan | CL0062 | ||||||||
| InterPro | IPR013057 | ||||||||
| TCDB | 2.A.18 | ||||||||
| |||||||||
The Amino Acid/Auxin Permease (AAAP) Family ( TC# 2.A.18) is a family of secondary carrier proteins, a member of the APC Superfamily that includes hundreds of proteins from plants, animals, fungi and lower eukaryotes. Six AAAPs in A. thaliana are well characterized and transport neutral and charged amino acids with varying specificities and affinities. [1] [2]
Function
Among animal AAAP family members are numerous growth regulating System A and System N isoforms, each exhibiting distinctive tissue and subcellular localizations. The different isoforms also exhibit different relative affinities for the amino acid substrates. Some catalyze H+ antiport and can function bidirectionally. Since Systems A are electrogenic which Systems N are not, the amino acid:cation stoichiometries may differ. [2] [3] [4] [5]
References
- ^ Fischer WN, Loo DD, Koch W, Ludewig U, Boorer KJ, Tegeder M, et al. (March 2002). "Low and high affinity amino acid H+-cotransporters for cellular import of neutral and charged amino acids". The Plant Journal. 29 (6): 717–731. doi: 10.1046/j.1365-313x.2002.01248.x. PMID 12148530.
- ^ a b Saier Jr MH. "2.A.18 The Amino Acid/Auxin Permease (AAAP) Family". Transporter Classification Database. Saier Lab Bioinformatics Group.
- ^ Chaudhry FA, Krizaj D, Larsson P, Reimer RJ, Wreden C, Storm-Mathisen J, et al. (December 2001). "Coupled and uncoupled proton movement by amino acid transport system N". The EMBO Journal. 20 (24): 7041–7051. doi: 10.1093/emboj/20.24.7041. PMC 125789. PMID 11742981.
- ^ Chaudhry FA, Schmitz D, Reimer RJ, Larsson P, Gray AT, Nicoll R, et al. (January 2002). "Glutamine uptake by neurons: interaction of protons with system a transporters". The Journal of Neuroscience. 22 (1): 62–72. doi: 10.1523/JNEUROSCI.22-01-00062.2002. PMC 6757603. PMID 11756489.
- ^ Varoqui H, Zhu H, Yao D, Ming H, Erickson JD (February 2000). "Cloning and functional identification of a neuronal glutamine transporter". The Journal of Biological Chemistry. 275 (6): 4049–4054. doi: 10.1074/jbc.275.6.4049. PMID 10660562.
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