From Wikipedia, the free encyclopedia
Protein-coding gene in the species Homo sapiens
Rh family, B glycoprotein , also known as RHBG , is an
ammonia transporter
protein which in humans is encoded by the RHBG
gene .
[5]
[6]
Function
RHBG and RHCG are non-erythroid members of the
Rhesus (Rh) protein family that are mainly expressed in the
kidney and belong to the methylammonium-ammonium permease/
ammonia transporters superfamily. Rh family proteins are all predicted to be
transmembrane proteins with 12 membrane spanning domains and intracytoplasmic N- and C-termini.
[5]
References
Further reading
Huang CH, Liu PZ (2001). "New insights into the Rh superfamily of genes and proteins in erythroid cells and nonerythroid tissues". Blood Cells Mol. Dis . 27 (1): 90–101.
doi :
10.1006/bcmd.2000.0355 .
PMID
11358367 .
Liu Z, Chen Y, Mo R, et al. (2000).
"Characterization of human RhCG and mouse Rhcg as novel nonerythroid Rh glycoprotein homologues predominantly expressed in kidney and testis" . J. Biol. Chem . 275 (33): 25641–51.
doi :
10.1074/jbc.M003353200 .
PMID
10852913 .
Liu Z, Peng J, Mo R, et al. (2001).
"Rh type B glycoprotein is a new member of the Rh superfamily and a putative ammonia transporter in mammals" . J. Biol. Chem . 276 (2): 1424–33.
doi :
10.1074/jbc.M007528200 .
PMID
11024028 .
Strausberg RL, Feingold EA, Grouse LH, et al. (2003).
"Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences" . Proc. Natl. Acad. Sci. U.S.A . 99 (26): 16899–903.
Bibcode :
2002PNAS...9916899M .
doi :
10.1073/pnas.242603899 .
PMC
139241 .
PMID
12477932 .
Ota T, Suzuki Y, Nishikawa T, et al. (2004).
"Complete sequencing and characterization of 21,243 full-length human cDNAs" . Nat. Genet . 36 (1): 40–5.
doi :
10.1038/ng1285 .
PMID
14702039 .
Ludewig U (2005).
"Electroneutral ammonium transport by basolateral rhesus B glycoprotein" . J. Physiol . 559 (Pt 3): 751–9.
doi :
10.1113/jphysiol.2004.067728 .
PMC
1665183 .
PMID
15284342 .
Gerhard DS, Wagner L, Feingold EA, et al. (2004).
"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)" . Genome Res . 14 (10B): 2121–7.
doi :
10.1101/gr.2596504 .
PMC
528928 .
PMID
15489334 .
Lopez C, Métral S, Eladari D, et al. (2005).
"The ammonium transporter RhBG: requirement of a tyrosine-based signal and ankyrin-G for basolateral targeting and membrane anchorage in polarized kidney epithelial cells" . J. Biol. Chem . 280 (9): 8221–8.
doi :
10.1074/jbc.M413351200 .
PMID
15611082 .
Zidi-Yahiaoui N, Mouro-Chanteloup I, D'Ambrosio AM, et al. (2006).
"Human Rhesus B and Rhesus C glycoproteins: properties of facilitated ammonium transport in recombinant kidney cells" . Biochem. J . 391 (Pt 1): 33–40.
doi :
10.1042/BJ20050657 .
PMC
1237136 .
PMID
15929723 .
Huang CH, Peng J (2005).
"Evolutionary conservation and diversification of Rh family genes and proteins" . Proc. Natl. Acad. Sci. U.S.A . 102 (43): 15512–7.
Bibcode :
2005PNAS..10215512H .
doi :
10.1073/pnas.0507886102 .
PMC
1266151 .
PMID
16227429 .
Gregory SG, Barlow KF, McLay KE, et al. (2006).
"The DNA sequence and biological annotation of human chromosome 1" . Nature . 441 (7091): 315–21.
Bibcode :
2006Natur.441..315G .
doi :
10.1038/nature04727 .
PMID
16710414 .
This article incorporates text from the
United States National Library of Medicine , which is in the
public domain .
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