Polygodial’s primary antifungal action is as a nonionic
surfactant, disrupting the lipid-protein interface of integral proteins nonspecifically, denaturing their functional conformation. It is also likely that polygodial permeates by passive diffusion across the plasma membrane, and once inside the cells may react with a variety of intracellular compounds.[18]
It is also an
insecticide with antifeedant properties, which causes insects to starve.
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