Matrix Gla protein (MGP) is member of a family of
vitamin K2 dependent,
Gla-containing
proteins. MGP has a high
affinity binding to
calciumions, similar to other Gla-containing proteins. The protein acts as an inhibitor of
vascularmineralization and plays a role in bone organization.[5][6]
MGP is found in a number of body
tissues in mammals, birds, and fish. Its
mRNA is present in bone, cartilage, heart, and kidney.[7]
It is present in
bone together with the related vitamin K2-dependent protein
osteocalcin. In bone, its production is increased by
vitamin D.
Genetics
The MGP was linked to the short arm of
chromosome 12 in 1990.[8] Its mRNA sequence length is 585 bases long in humans.[9]
^
abLuo G, Ducy P, McKee MD, Pinero GJ, Loyer E, Behringer RR, Karsenty G (March 1997). "Spontaneous calcification of arteries and cartilage in mice lacking matrix GLA protein". Nature. 386 (6620): 78–81.
Bibcode:
1997Natur.386...78L.
doi:
10.1038/386078a0.
PMID9052783.
S2CID4335985.
^Pinto JP, Conceição N, Gavaia PJ, Cancela ML (2003). "Matrix Gla protein gene expression and protein accumulation colocalize with cartilage distribution during development of the teleost fish Sparus aurata". Bone. 32 (3): 201–10.
doi:
10.1016/S8756-3282(02)00981-X.
PMID12667547.
^Munroe PB, Olgunturk RO, Fryns JP, Van Maldergem L, Ziereisen F, Yuksel B, Gardiner RM, Chung E (1999). "Mutations in the gene encoding the human matrix Gla protein cause Keutel syndrome". Nat. Genet. 21 (1): 142–4.
doi:
10.1038/5102.
PMID9916809.
S2CID1244954.