From Wikipedia, the free encyclopedia
Protein-coding gene in the species Homo sapiens
Laminin subunit alpha-1 is a
protein that in humans is encoded by the LAMA1
gene .
[5]
[6]
Interactions
Laminin, alpha 1 has been shown to
interact with
FBLN2 .
[7]
[8]
Role in pathology
Mutations of the LAMA1 gene cause the
Poretti–Boltshauser syndrome .
References
^
a
b
c
GRCh38: Ensembl release 89: ENSG00000101680 –
Ensembl , May 2017
^
a
b
c
GRCm38: Ensembl release 89: ENSMUSG00000032796 –
Ensembl , May 2017
^
"Human PubMed Reference:" . National Center for Biotechnology Information, U.S. National Library of Medicine .
^
"Mouse PubMed Reference:" . National Center for Biotechnology Information, U.S. National Library of Medicine .
^ Nagayoshi T, Mattei MG, Passage E, Knowlton R, Chu ML, Uitto J (January 1990). "Human laminin A chain (LAMA) gene: chromosomal mapping to locus 18p11.3". Genomics . 5 (4): 932–5.
doi :
10.1016/0888-7543(89)90136-5 .
PMID
2591971 .
^
"Entrez Gene: LAMA1 laminin, alpha 1" .
^ Utani A, Nomizu M, Yamada Y (January 1997).
"Fibulin-2 binds to the short arms of laminin-5 and laminin-1 via conserved amino acid sequences" . J. Biol. Chem . 272 (5): 2814–20.
doi :
10.1074/jbc.272.5.2814 .
ISSN
0021-9258 .
PMID
9006922 .
S2CID
24800195 .
^ Talts JF, Sasaki T, Miosge N, Göhring W, Mann K, Mayne R, Timpl R (November 2000).
"Structural and functional analysis of the recombinant G domain of the laminin alpha4 chain and its proteolytic processing in tissues" . J. Biol. Chem . 275 (45): 35192–9.
doi :
10.1074/jbc.M003261200 .
ISSN
0021-9258 .
PMID
10934193 .
S2CID
36521395 .
Further reading
Haaparanta T, Uitto J, Ruoslahti E, Engvall E (1991). "Molecular cloning of the cDNA encoding human laminin A chain". Matrix . 11 (3): 151–60.
doi :
10.1016/s0934-8832(11)80153-8 .
PMID
1714537 .
Nissinen M, Vuolteenaho R, Boot-Handford R, et al. (1991).
"Primary structure of the human laminin A chain. Limited expression in human tissues" . Biochem. J . 276 ( Pt 2) (Pt 2): 369–79.
doi :
10.1042/bj2760369 .
PMC
1151101 .
PMID
2049067 .
Taraboletti G, Rao CN, Krutzsch HC, et al. (1990).
"Sulfatide-binding domain of the laminin A chain" . J. Biol. Chem . 265 (21): 12253–8.
doi :
10.1016/S0021-9258(19)38338-3 .
PMID
2373692 .
Olsen D, Nagayoshi T, Fazio M, et al. (1989). "Human laminin: cloning and sequence analysis of cDNAs encoding A, B1 and B2 chains, and expression of the corresponding genes in human skin and cultured cells". Lab. Invest . 60 (6): 772–82.
PMID
2733383 .
Leivo I, Engvall E (1986).
"C3d fragment of complement interacts with laminin and binds to basement membranes of glomerulus and trophoblast" . J. Cell Biol . 103 (3): 1091–100.
doi :
10.1083/jcb.103.3.1091 .
PMC
2114300 .
PMID
3488995 .
Wewer UM, Gerecke DR, Durkin ME, et al. (1995). "Human beta 2 chain of laminin (formerly S chain): cDNA cloning, chromosomal localization, and expression in carcinomas". Genomics . 24 (2): 243–52.
doi :
10.1006/geno.1994.1612 .
PMID
7698745 .
Yamada H, Shimizu T, Tanaka T, et al. (1994). "Dystroglycan is a binding protein of laminin and merosin in peripheral nerve". FEBS Lett . 352 (1): 49–53.
doi :
10.1016/0014-5793(94)00917-1 .
PMID
7925941 .
S2CID
17529055 .
Moser TL, Enghild JJ, Pizzo SV, Stack MS (1993).
"The extracellular matrix proteins laminin and fibronectin contain binding domains for human plasminogen and tissue plasminogen activator" . J. Biol. Chem . 268 (25): 18917–23.
doi :
10.1016/S0021-9258(17)46714-7 .
PMID
8360181 .
Yurchenco PD, Sung U, Ward MD, et al. (1993).
"Recombinant laminin G domain mediates myoblast adhesion and heparin binding" . J. Biol. Chem . 268 (11): 8356–65.
doi :
10.1016/S0021-9258(18)53103-3 .
PMID
8463343 .
Ancsin JB, Kisilevsky R (1997).
"Characterization of high affinity binding between laminin and the acute-phase protein, serum amyloid A" . J. Biol. Chem . 272 (1): 406–13.
doi :
10.1074/jbc.272.1.406 .
PMID
8995276 .
S2CID
37912337 .
Zahedi K (1997).
"Characterization of the binding of serum amyloid P to laminin" . J. Biol. Chem . 272 (4): 2143–8.
doi :
10.1074/S0021-9258(19)78482-8 .
PMID
8999915 .
Utani A, Nomizu M, Yamada Y (1997).
"Fibulin-2 binds to the short arms of laminin-5 and laminin-1 via conserved amino acid sequences" . J. Biol. Chem . 272 (5): 2814–20.
doi :
10.1074/jbc.272.5.2814 .
PMID
9006922 .
S2CID
24800195 .
Cáceres J, Brandan E (1997). "Interaction between Alzheimer's disease beta A4 precursor protein (APP) and the extracellular matrix: evidence for the participation of heparan sulfate proteoglycans". J. Cell. Biochem . 65 (2): 145–58.
doi :
10.1002/(SICI)1097-4644(199705)65:2<145::AID-JCB2>3.0.CO;2-U .
PMID
9136074 .
S2CID
43911847 .
Chen M, Marinkovich MP, Veis A, et al. (1997).
"Interactions of the amino-terminal noncollagenous (NC1) domain of type VII collagen with extracellular matrix components. A potential role in epidermal-dermal adherence in human skin" . J. Biol. Chem . 272 (23): 14516–22.
doi :
10.1074/jbc.272.23.14516 .
PMID
9169408 .
S2CID
7310763 .
Schuger L, Skubitz AP, Zhang J, et al. (1997).
"Laminin α1 Chain Synthesis in the Mouse Developing Lung: Requirement for Epithelial–Mesenchymal Contact and Possible Role in Bronchial Smooth muscle Development" . J. Cell Biol . 139 (2): 553–62.
doi :
10.1083/jcb.139.2.553 .
PMC
2139794 .
PMID
9334356 .
Mrowiec T, Melchar C, Górski A (1998). "HIV-protein-mediated alterations in T cell interactions with the extracellular matrix proteins and endothelium". Arch. Immunol. Ther. Exp. (Warsz.) . 45 (2–3): 255–9.
PMID
9597096 .
O'Grady P, Thai TC, Saito H (1998).
"The Laminin–Nidogen Complex is a Ligand for a Specific Splice Isoform of the Transmembrane Protein Tyrosine Phosphatase LAR" . J. Cell Biol . 141 (7): 1675–84.
doi :
10.1083/jcb.141.7.1675 .
PMC
2133008 .
PMID
9647658 .
Ettner N, Göhring W, Sasaki T, et al. (1998).
"The N-terminal globular domain of the laminin alpha1 chain binds to alpha1beta1 and alpha2beta1 integrins and to the heparan sulfate-containing domains of perlecan" . FEBS Lett . 430 (3): 217–21.
doi :
10.1016/S0014-5793(98)00601-2 .
PMID
9688542 .
S2CID
84569969 .
Ludwig HC, Rausch S, Schallock K, Markakis E (1999). "Expression of CD 73 (ecto-5'-nucleotidase) in 165 glioblastomas by immunohistochemistry and electronmicroscopic histochemistry". Anticancer Res . 19 (3A): 1747–52.
PMID
10470109 .