From Wikipedia, the free encyclopedia
Protein found in humans
COL25A1 Identifiers
Aliases
COL25A1 , AMY, CLAC, CLAC-P, CLACP, CFEOM5, Collagen, type XXV, alpha 1, collagen type XXV alpha 1, collagen type XXV alpha 1 chainExternal IDs
OMIM :
610004
MGI :
1924268
HomoloGene :
57111
GeneCards :
COL25A1
Wikidata
Collagen alpha-1(XXV) chain is a
protein that in humans is encoded by the COL25A1
gene .
[5]
[6]
COL25A1 is a brain-specific membrane-bound collagen. Proteolytic processing releases CLAC, a soluble form of COL25A1 containing the extracellular collagen domains that associates with senile plaques in Alzheimer disease (AD; MIM 104300) brains (Osada et al., 2005).[supplied by OMIM]
[6]
Interactions
Collagen, type XXV, alpha 1 has been shown to
interact with
Amyloid precursor protein .
[5]
References
^
a
b
c
GRCh38: Ensembl release 89: ENSG00000188517 –
Ensembl , May 2017
^
a
b
c
GRCm38: Ensembl release 89: ENSMUSG00000058897 –
Ensembl , May 2017
^
"Human PubMed Reference:" . National Center for Biotechnology Information, U.S. National Library of Medicine .
^
"Mouse PubMed Reference:" . National Center for Biotechnology Information, U.S. National Library of Medicine .
^
a
b Hashimoto T, Wakabayashi T, Watanabe A, Kowa H, Hosoda R, Nakamura A, Kanazawa I, Arai T, Takio K, Mann DM, Iwatsubo T (Apr 2002).
"CLAC: a novel Alzheimer amyloid plaque component derived from a transmembrane precursor, CLAC-P/collagen type XXV" . EMBO J . 21 (7): 1524–34.
doi :
10.1093/emboj/21.7.1524 .
PMC
125364 .
PMID
11927537 .
^
a
b
"Entrez Gene: COL25A1 collagen, type XXV, alpha 1" .
Further reading
Kakuyama H, Söderberg L, Horigome K, et al. (2006). "CLAC binds to aggregated Abeta and Abeta fragments, and attenuates fibril elongation". Biochemistry . 44 (47): 15602–9.
doi :
10.1021/bi051263e .
PMID
16300410 .
Söderberg L, Dahlqvist C, Kakuyama H, et al. (2005). "Collagenous Alzheimer amyloid plaque component assembles amyloid fibrils into protease resistant aggregates". FEBS J . 272 (9): 2231–6.
doi :
10.1111/j.1742-4658.2005.04647.x .
hdl :
10616/39314 .
PMID
15853808 .
S2CID
26505595 .
Osada Y, Hashimoto T, Nishimura A, et al. (2005).
"CLAC binds to amyloid beta peptides through the positively charged amino acid cluster within the collagenous domain 1 and inhibits formation of amyloid fibrils" . J. Biol. Chem . 280 (9): 8596–605.
doi :
10.1074/jbc.M413340200 .
PMID
15615705 .
Söderberg L, Kakuyama H, Möller A, et al. (2005).
"Characterization of the Alzheimer's disease-associated CLAC protein and identification of an amyloid beta-peptide-binding site" . J. Biol. Chem . 280 (2): 1007–15.
doi :
10.1074/jbc.M403628200 .
PMID
15522881 .
Kowa H, Sakakura T, Matsuura Y, et al. (2004).
"Mostly separate distributions of CLAC- versus Abeta40- or thioflavin S-reactivities in senile plaques reveal two distinct subpopulations of beta-amyloid deposits" . Am. J. Pathol . 165 (1): 273–81.
doi :
10.1016/s0002-9440(10)63295-6 .
PMC
1618534 .
PMID
15215182 .
Söderberg L, Zhukareva V, Bogdanovic N, et al. (2004).
"Molecular identification of AMY, an Alzheimer disease amyloid-associated protein" . J. Neuropathol. Exp. Neurol . 62 (11): 1108–17.
doi :
10.1093/jnen/62.11.1108 .
PMID
14656069 .
Strausberg RL, Feingold EA, Grouse LH, et al. (2003).
"Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences" . Proc. Natl. Acad. Sci. U.S.A . 99 (26): 16899–903.
Bibcode :
2002PNAS...9916899M .
doi :
10.1073/pnas.242603899 .
PMC
139241 .
PMID
12477932 .