High affinity immunoglobulin epsilon receptor subunit beta is a
protein that in humans is encoded by the MS4A2gene.[5][6]
Function
The allergic response involves the binding of
allergen to receptor-bound
IgE followed by cell activation and the release of mediators responsible for the manifestations of
allergy. The
IgE-receptor, a tetramer composed of an alpha, beta, and 2 disulfide-linked gamma chains, is found on the surface of
mast cells and
basophils. This gene encodes the beta subunit of the high affinity IgE receptor which is a member of the
membrane-spanning 4A gene family. Members of this nascent protein family are characterized by common structural features and similar intron/exon splice boundaries and display unique expression patterns among hematopoietic cells and nonlymphoid tissues. This family member is localized to 11q12, among a cluster of family members.[6]
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doi:
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PMID7920628.
S2CID24026689.
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PMID8094113.
S2CID54428682.
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