From Wikipedia, the free encyclopedia
Mammalian protein found in Homo sapiens
GDP-fucose protein O -fucosyltransferase 2 (POFUT2) is an
enzyme responsible for adding
fucose sugars in
O linkage to
serine or
threonine residues in
Thrombospondin repeats.
[5] The protein is an inverting
glycosyltransferase , which means that the enzyme uses GDP-β-L-fucose as a donor substrate and transfers the fucose in O linkage to the protein producing fucose-α-O -serine/threonine.
Almost all glycosyltransferases reside in the
Golgi apparatus . However, POFUT2 as well as the related
enzyme
POFUT1 have recently been shown to reside in the
endoplasmic reticulum .
The
malaria parasite
Plasmodium falciparum requires POFUT2 for efficient transmission to
mosquitoes and infection of human
liver cells .
[6]
See also
References
^
a
b
c
GRCh38: Ensembl release 89: ENSG00000186866 –
Ensembl , May 2017
^
a
b
c
GRCm38: Ensembl release 89: ENSMUSG00000020260 –
Ensembl , May 2017
^
"Human PubMed Reference:" . National Center for Biotechnology Information, U.S. National Library of Medicine .
^
"Mouse PubMed Reference:" . National Center for Biotechnology Information, U.S. National Library of Medicine .
^
GDP-fucose protein O-fucosyltransferase 2, The Universal Protein Resource
^ Lopaticki S, Yang AS, John A, Scott NE, Lingford JP, O'Neill MT, et al. (September 2017).
"Protein O-fucosylation in Plasmodium falciparum ensures efficient infection of mosquito and vertebrate hosts" . Nature Communications . 8 (1): 561.
Bibcode :
2017NatCo...8..561L .
doi :
10.1038/s41467-017-00571-y .
PMC
5601480 .
PMID
28916755 .
External links
Activity Regulation Classification Kinetics Types