From Wikipedia, the free encyclopedia
Protein-coding gene in the species Homo sapiens
Galactosylgalactosylxylosylprotein 3-beta-glucuronosyltransferase 3 is an
enzyme that in humans is encoded by the B3GAT3
gene .
[5]
[6]
The protein encoded by this gene is a member of the
glucuronyltransferase gene family, enzymes that exhibit strict acceptor specificity, recognizing nonreducing terminal sugars and their
anomeric linkages . This gene product catalyzes the formation of the
glycosaminoglycan -protein linkage by way of a glucuronyl transfer reaction in the final step of the biosynthesis of the linkage region of
proteoglycans .
[6]
References
^
a
b
c
GRCh38: Ensembl release 89: ENSG00000149541 –
Ensembl , May 2017
^
a
b
c
GRCm38: Ensembl release 89: ENSMUSG00000071649 –
Ensembl , May 2017
^
"Human PubMed Reference:" . National Center for Biotechnology Information, U.S. National Library of Medicine .
^
"Mouse PubMed Reference:" . National Center for Biotechnology Information, U.S. National Library of Medicine .
^ Kitagawa H, Tone Y, Tamura J, Neumann KW, Ogawa T, Oka S, Kawasaki T, Sugahara K (Apr 1998).
"Molecular cloning and expression of glucuronyltransferase I involved in the biosynthesis of the glycosaminoglycan-protein linkage region of proteoglycans" . J Biol Chem . 273 (12): 6615–8.
doi :
10.1074/jbc.273.12.6615 .
PMID
9506957 .
^
a
b
"Entrez Gene: B3GAT3 beta-1,3-glucuronyltransferase 3 (glucuronosyltransferase I)" .
External links
Human
B3GAT3 genome location and
B3GAT3 gene details page in the
UCSC Genome Browser .
Overview of all the structural information available in the
PDB for
UniProt :
O94766 (Human Galactosylgalactosylxylosylprotein 3-beta-glucuronosyltransferase 3 (B3GAT3)) at the
PDBe-KB .
Further reading
Rual JF, Venkatesan K, Hao T, et al. (2005). "Towards a proteome-scale map of the human protein-protein interaction network". Nature . 437 (7062): 1173–8.
Bibcode :
2005Natur.437.1173R .
doi :
10.1038/nature04209 .
PMID
16189514 .
S2CID
4427026 .
Venkatesan N, Barré L, Benani A, et al. (2005).
"Stimulation of proteoglycan synthesis by glucuronosyltransferase-I gene delivery: A strategy to promote cartilage repair" . Proc. Natl. Acad. Sci. U.S.A . 101 (52): 18087–92.
doi :
10.1073/pnas.0404504102 .
PMC
535800 .
PMID
15601778 .
Gulberti S, Lattard V, Fondeur M, et al. (2005).
"Phosphorylation and sulfation of oligosaccharide substrates critically influence the activity of human beta1,4-galactosyltransferase 7 (GalT-I) and beta1,3-glucuronosyltransferase I (GlcAT-I) involved in the biosynthesis of the glycosaminoglycan-protein linkage region of proteoglycans" . J. Biol. Chem . 280 (2): 1417–25.
doi :
10.1074/jbc.M411552200 .
PMID
15522873 .
Gerhard DS, Wagner L, Feingold EA, et al. (2004).
"The Status, Quality, and Expansion of the NIH Full-Length cDNA Project: The Mammalian Gene Collection (MGC)" . Genome Res . 14 (10B): 2121–7.
doi :
10.1101/gr.2596504 .
PMC
528928 .
PMID
15489334 .
Gulberti S, Fournel-Gigleux S, Mulliert G, et al. (2003).
"The functional glycosyltransferase signature sequence of the human beta 1,3-glucuronosyltransferase is a XDD motif" . J. Biol. Chem . 278 (34): 32219–26.
doi :
10.1074/jbc.M207899200 .
PMID
12794088 .
Strausberg RL, Feingold EA, Grouse LH, et al. (2003).
"Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences" . Proc. Natl. Acad. Sci. U.S.A . 99 (26): 16899–903.
Bibcode :
2002PNAS...9916899M .
doi :
10.1073/pnas.242603899 .
PMC
139241 .
PMID
12477932 .
Kitagawa H, Taoka M, Tone Y, Sugahara K (2001).
"Human glycosaminoglycan glucuronyltransferase I gene and a related processed pseudogene: genomic structure, chromosomal mapping and characterization" . Biochem. J . 358 (Pt 3): 539–46.
doi :
10.1042/0264-6021:3580539 .
PMC
1222090 .
PMID
11535117 .
Pedersen LC, Tsuchida K, Kitagawa H, et al. (2000).
"Heparan/chondroitin sulfate biosynthesis. Structure and mechanism of human glucuronyltransferase I" . J. Biol. Chem . 275 (44): 34580–5.
doi :
10.1074/jbc.M007399200 .
PMID
10946001 .
Ouzzine M, Gulberti S, Netter P, et al. (2000).
"Structure/function of the human Ga1beta1,3-glucuronosyltransferase. Dimerization and functional activity are mediated by two crucial cysteine residues" . J. Biol. Chem . 275 (36): 28254–60.
doi :
10.1074/jbc.M002182200 .
PMID
10842173 .
Tone Y, Kitagawa H, Imiya K, et al. (1999).
"Characterization of recombinant human glucuronyltransferase I involved in the biosynthesis of the glycosaminoglycan-protein linkage region of proteoglycans" . FEBS Lett . 459 (3): 415–20.
doi :
10.1016/S0014-5793(99)01287-9 .
PMID
10526176 .
S2CID
7878952 .
Herman T, Horvitz HR (1999).
"Three proteins involved in Caenorhabditis elegans vulval invagination are similar to components of a glycosylation pathway" . Proc. Natl. Acad. Sci. U.S.A . 96 (3): 974–9.
Bibcode :
1999PNAS...96..974H .
doi :
10.1073/pnas.96.3.974 .
PMC
15335 .
PMID
9927678 .
PDB gallery
1fgg : CRYSTAL STRUCTURE OF 1,3-GLUCURONYLTRANSFERASE I (GLCAT-I) COMPLEXED WITH GAL-GAL-XYL, UDP, AND MN2+
1kws : CRYSTAL STRUCTURE OF BETA1,3-GLUCURONYLTRANSFERASE I IN COMPLEX WITH THE ACTIVE UDP-GLCUA DONOR