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Bioinformatician
Aviv Regev (born 11 July 1971)
[3] is a
computational biologist and systems biologist and Executive Vice President and Head of
Genentech Research and Early Development in Genentech/Roche.
[4] She is a core member (on leave) at the
Broad Institute of MIT and Harvard and professor (on leave) at the Department of Biology of the
Massachusetts Institute of Technology .
[5] Regev is a pioneer of
single cell genomics and of computational and systems biology of
gene regulatory circuits . She founded and leads the
Human Cell Atlas project,
[6] together with
Sarah Teichmann .
Education
Regev studied at the
Adi Lautman Interdisciplinary Program for Outstanding Students of
Tel Aviv University , where she completed her PhD under the supervision of
Eva Jablonka ,
[7] and
Ehud Shapiro .
[8]
Career and research
In 2020, Regev became the Head and Executive Vice President of
Genentech Research and Early Development, based in South San Francisco, and a member of the extended Corporate Executive Committee of Roche.
[9]
[10] Previously, she was a Core Institute Member (now on leave), Chair of the Faculty, Founding Director of the Klarman Cell Observatory and co-Director Cell Circuits Program at the
Broad Institute of MIT and Harvard. She was also a professor in the Department of Biology at the Massachusetts Institute of Technology (now on leave), as well as an Investigator at the Howard Hughes Medical Institute. Regev's research
[11] includes work on
gene expression
[12]
[13] (with
Eran Segal and
David Botstein ), and the use of
π-calculus to represent biochemical processes.
[14]
[15]
[16] Regev's team has been a leading pioneer of single-cell genomics experimental and computational methods.
[17] In 2014, she pitched the idea of the creation of Human Cell Atlas,
[18] a project to describe all
cell types in the
human body . Regev founded the
Human Cell Atlas together with
Sarah Teichmann along with collaborators all over the world.[
citation needed ]
Single Cell Genomics
Regev's lab pioneered the development and application of many of the key experimental and computational advances for single cell and spatial genomics, especially single cell
RNA-Seq (scRNA-seq).
Awards and honors
Regev is a fellow of the International Society of Computational Biology (ISCB) (2017),
[19] a Helmholtz Fellow (2020),
[20] and a fellow of the American Association for Cancer Research (AACR) (2021).
[21] She is a member of the US National Academy of Sciences (NAS, elected 2019)
[22] and of the US National Academy of Medicine (NAM, elected 2020).
[23]
25th
L'Oréal-UNESCO For Women in Science Awards (Laureate for North America), 2023
[24]
Elected to the American Academy of Arts and Sciences, 2022
[25]
Anderson Lecture, University of Virginia, 2022
[26]
Nakasone Award from the Human Frontiers Science Program (2022)
[27]
Honorary doctorate, ETH Zurich (2021)
[28]
Ernst Schering Prize (2021)
[29]
James Prize in Science and Technology Integration, National Academy of Sciences (2021)
[30]
Vanderbilt Prize (2021)
[31]
She was awarded the 25th
Keio Medical Science Prize in 2020.
[32]
[33]
AACR-Irving Weinstein Foundation Distinguished Lecture (2021)
[34]
Lurie Prize from the Foundation for the NIH (FNIH) (2020)
[35]
Mendel Lecture, European Society of Human Genetics (2020)
[36]
Jonathan Kraft Prize from Massachusetts General Hospital (2020)
[37]
FASEB Excellence in Science Mid-Career Investigator Award (2019)
[38]
She was elected a member of the
National Academy of Sciences (NAS) in 2019.
[39]
She also served on the Life Sciences jury for the
Infosys Prize in 2018.
Weatherall Lecture, University Oxford, UK (2018)
[40]
Harvey Lecture, Harvey Society, New York (2018)
[41]
McCormick Lecture, Stanford University (2018)
[42]
Paul Marks Prize for Cancer Research (2017).
[43]
ISCB Innovator Award in 2017.
[2]
[44]
Earl and Thressa Stadtman Scholar Award from the American Society of Biochemistry and Molecular Biology (ASBMB) (2014)
[45]
Burroughs Wellcome Fund Career Award.
[46]
In 2008, she was also awarded the
NIH Director's Pioneer Award .
[47]
[48]
Regev was awarded the
Overton Prize in 2008 for "outstanding accomplishment to a scientist in the early to mid stage of his or her career".
[1]
References
^
a
b Sansom, C.; Morrison Mckay, B. J. (2008). Bourne, Philip E. (ed.).
"ISCB Honors David Haussler and Aviv Regev" .
PLOS Computational Biology . 4 (7): e1000101.
Bibcode :
2008PLSCB...4E0101S .
doi :
10.1371/journal.pcbi.1000101 .
PMC
2536508 .
PMID
18795145 .
^
a
b Fogg, Christiana N.; Kovats, Diane E.; Berger, Bonnie (2017).
"2017 ISCB Innovator Award: Aviv Regev" .
PLOS Computational Biology . 13 (6): e1005558.
Bibcode :
2017PLSCB..13E5558F .
doi :
10.1371/journal.pcbi.1005558 .
ISSN
1553-7358 .
PMC
5493285 .
PMID
28665936 .
^
a
b
"Aviv Regev" (PDF) . broadinstitute.org . Archived from
the original (PDF) on 16 November 2017. Retrieved 2 December 2021 .
^
GENENTECH EXECUTIVE COMMITTEE , accessed 6 August 2020.
^
"Aviv Regev at MIT" . biology.mit.edu . Archived from
the original on 6 April 2017. Retrieved 5 November 2017 .
^ Nowogrodzki, Anna (5 July 2017).
"How to build a human cell atlas" .
Nature . 547 (7661): 24–26.
Bibcode :
2017Natur.547...24N .
doi :
10.1038/547024a .
PMID
28682347 .
S2CID
211067156 .
^ Regev, A.; Lamb, M. J.; Jablonka, E. (1998).
"The Role of DNA Methylation in Invertebrates: Developmental Regulation or Genome Defense?" .
Molecular Biology and Evolution . 15 (7): 880.
doi :
10.1093/oxfordjournals.molbev.a025992 .
ISSN
0737-4038 .
^ Regev, A.; Shapiro, E. (2002).
"Cellular abstractions: Cells as computation" . Nature . 419 (6905): 343.
Bibcode :
2002Natur.419..343R .
doi :
10.1038/419343a .
PMC
3842595 .
PMID
12353013 .
^ Taylor, Nick Paul (11 May 2020).
"Genentech lures Regev from Broad Institute to lead research and early development" . fiercebiotech.com . Retrieved 25 May 2020 .
^
"Changes to the Roche Enlarged Corporate Executive Committee" (Press release). Basel, Switzerland: F. Hoffmann-La Roche Ltd. globenewswire. 11 May 2020. Retrieved 25 May 2020 .
^
Search Results for author Regev A on
PubMed .
^ Segal, E.; Shapira, M.; Regev, A.; Pe'er, D.; Botstein, D.; Koller, D.; Friedman, N. (2003). "Module networks: Identifying regulatory modules and their condition-specific regulators from gene expression data".
Nature Genetics . 34 (2): 166–176.
doi :
10.1038/ng1165 .
PMID
12740579 .
S2CID
6146032 .
^ Segal, E.; Friedman, N.; Koller, D.; Regev, A. (2004).
"A module map showing conditional activity of expression modules in cancer" .
Nature Genetics . 36 (10): 1090–1098.
doi :
10.1038/ng1434 .
PMC
2271138 .
PMID
15448693 .
^ Regev, A.; Silverman, W.; Shapiro, E. (2001). "Representation and simulation of biochemical processes using the pi-calculus process algebra".
Pacific Symposium on Biocomputing : 459–470.
doi :
10.1142/9789814447362_0045 .
ISBN
978-981-02-4515-3 .
PMID
11262964 .
^ Priami, C.; et al. (2001).
"Application of a stochastic name-passing calculus to representation and simulation of molecular processes" (PDF) . Information Processing Letters . 80 : 25–31.
doi :
10.1016/S0020-0190(01)00214-9 .
^
Study provides insight into regenerative potential of prostate gland , News Medical, accessed 4 May 2020.
^
"Aviv Regev" . HHMI.org . Retrieved 11 May 2020 .
^
The Human Cell Atlas – Aviv Regev , retrieved 30 May 2022
^
"2017 ISCB Innovator Award: Aviv Regev" . www.iscb.org . Retrieved 14 March 2022 .
^
"Event – Helmholtz Zentrum München" . www.helmholtz-munich.de . Retrieved 14 March 2022 .
^
"Aviv Regev, PhD, FAACR | Scientific Awards | AACR" . American Association for Cancer Research (AACR) . Retrieved 14 March 2022 .
^
"Aviv Regev" . www.nasonline.org . Retrieved 14 March 2022 .
^
"National Academy of Medicine Elects 100 New Members" . National Academy of Medicine . 19 October 2020. Retrieved 14 March 2022 .
^
"Discover the laureates of the 25th L'Oréal-UNESCO For Women in Science International Awards | UNESCO" . www.unesco.org . Retrieved 2 June 2023 .
^
"New Members" . American Academy of Arts & Sciences . Retrieved 30 May 2022 .
^
"The Events Calendar" .
^
"Press Release – 2022 HFSP Nakasone Award" .
^ Foppa, Carolin Arndt (22 November 2021).
"Pioneer in bioinformatics receives ETH Honorary doctorate" . bsse.ethz.ch . Retrieved 18 March 2022 .
^
"Ernst Schering Prize 2021 – Schering Stiftung" . Retrieved 18 March 2022 .
^
"James Prize in Science and Technology Integration" . www.nasonline.org . Retrieved 18 March 2022 .
^ Snyder, Bill.
"Regev receives Vanderbilt Prize in Biomedical Science" . Vanderbilt University . Retrieved 18 March 2022 .
^
"Award Ceremony for the 25th Keio Medical Science Prize" . keio.ac.jp . Retrieved 22 December 2020 .
^
"Announcement of the 25th Keio Medical Science Prize – News – Keio University Medical Science Fund" . www.ms-fund.keio.ac.jp . Retrieved 18 March 2022 .
^
"Aviv Regev, PhD, FAACR | Scientific Awards | AACR" . American Association for Cancer Research (AACR) . Retrieved 18 March 2022 .
^
"2020 FNIH Lurie Prize in Biomedical Sciences Winner Pioneered Innovative Techniques to Shed New Light on Human Health | The Foundation for the National Institutes of Health" . fnih.org . 18 June 2020. Retrieved 18 March 2022 .
^ Wimmer, Doris.
"Aviv Regev" . ESHG Conference 2020 . Retrieved 14 March 2022 .
^
"Kraft Prize Symposium" . Massachusetts General Hospital . Retrieved 14 March 2022 .
^
"Past Recipients" . www.faseb.org . Retrieved 14 March 2022 .
^
"2019 NAS Election" . nasonline.org . Retrieved 30 April 2019 .
^
"Weatherall Lectures — MRC Weatherall Institute of Molecular Medicine" . www.imm.ox.ac.uk . Retrieved 14 March 2022 .
^
"The Harvey Society: Series 113, Lecture 5" . harveysociety.org . Retrieved 14 March 2022 .
^
"MIT's Aviv Regev to present annual McCormick Lecture Feb. 1" . News Center (in Samoan). Retrieved 14 March 2022 .
^
"2017 Prize Winners" . Memorial Sloan Kettering Cancer Center. Retrieved 12 December 2017 .
^
"February 09, 2017: ISCB Announces 2017 Award Recipients" . iscb.org . Retrieved 10 February 2017 .
^
"Regev recognized for rigorous integration of experimental and computational approaches" . www.asbmb.org . Retrieved 14 March 2022 .
^
Dynamic single-cell imaging of direct reprogramming reveals an early specifying event – Nature Biotechnology: Aviv Regev, Ph.D. – Career Awards at the Scientific Interface; Ab initio reconstruction of cell type–specific transcriptomes in mouse reveals the conserved multi-exonic structure of lincRNAs – Nature Biotechnology: Aviv Regev, Ph.D. – Career Awards at the Scientific Interface .
^
"Three faculty win '08 NIH Pioneer Awards" . MIT News | Massachusetts Institute of Technology . 22 September 2008. Retrieved 6 March 2022 .
^
"2008 NIH Director's Pioneer Award" . Archived from
the original on 30 July 2019. Retrieved 30 July 2019 .
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