From Wikipedia, the free encyclopedia
Protein-coding gene in the species Homo sapiens
Apolipoprotein C-II (Apo-CII, or Apoc-II ), or apolipoprotein C2 is a
protein that in humans is encoded by the
APOC2
gene .
The protein encoded by this gene is secreted in plasma, where it is a component of
very low density lipoproteins and
chylomicrons . This protein activates the enzyme
lipoprotein lipase in capillaries,
[5] which hydrolyzes triglycerides and thus provides free
fatty acids for cells. Mutations in this gene cause
hyperlipoproteinemia type IB , characterized by
xanthomas ,
pancreatitis , and
hepatosplenomegaly , but no increased risk for
atherosclerosis . Lab tests will show elevated blood levels of triglycerides, cholesterol, and chylomicrons
[6]
Interactive pathway map
Click on genes, proteins and metabolites below to link to respective articles.
[§ 1]
[[File:
|alt=Statin pathway
]]
See also
References
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S2CID
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External links