Temporal range: Aptian–Recent
|Global range of Ephedra|
Alloephedra Tao JR et Yang Y., 2003. Chaetocladus Nelson 1866 nom. illeg. Liaoxia Cao et S.Q. Wu, 1996
Ephedra is a genus of gymnosperm shrubs. The various species of Ephedra are widespread in many arid regions of the world, ranging across southwestern North America, southern Europe, northern Africa, southwest and central Asia, northern China and western South America.  It is the only extant genus in its family, Ephedraceae, and order, Ephedrales and one of the three living members of the division Gnetophyta alongside Gnetum and Welwitschia.
In temperate climates, most Ephedra species grow on shores or in sandy soils with direct sun exposure. Common names in English include joint-pine, jointfir, Mormon-tea or Brigham tea. The Chinese name for Ephedra species is mahuang ( simplified Chinese: 麻黄; traditional Chinese: 麻黃; pinyin: máhuáng; Wade–Giles: ma-huang; lit. 'hemp yellow'). Ephedra is the origin of the name of the stimulant ephedrine, which the plants contain in significant concentrations.
The family Ephedraceae, of which Ephedra is the only genus, are gymnosperms, and generally shrubs, sometimes clambering vines, and rarely, small trees. Members of the genus frequently spread by the use of rhizomes. 
The stems are green and photosynthetic.  The leaves are opposite or whorled. The scalelike leaves fuse into a sheath at the base and this often sheds soon after development. There are no resin canals. 
The plants are mostly dioecious: with the pollen strobili in whorls of 1-10, each consisting of a series of decussate  bracts. The pollen is furrowed. The female strobili also occur in whorls, with bracts which fuse around a single ovule. There are generally 1-2 yellow to dark brown seeds per strobilus. 
The oldest known members of the genus are from the Early Cretaceous around 125 million years ago, with records being known from the Aptian- Albian of Argentina, China,  Portugal and the United States.  The fossil record of Ephedra outside of pollen disappears after the Early Cretaceous.  Molecular clock estimates have suggested that last common ancestor of living Ephedra species lived much more recently, during the Early Oligocene around 30 million years ago.  However, pollen modified from the ancestral condition of the genus with branched pseudosulci (grooves), which evolved in parallel in the living North American and Asian lineages is known from the Late Cretaceous, suggesting that the last common ancestor is at least this old. 
- Ephedra alata Decne. – North Africa, Arabian Peninsula
- Ephedra altissima Desf. non Bové (1834), non Delile (1813), non Buch (1828) – North Africa, Canary Islands
- Ephedra americana Humb. & Bonpl. ex Willd. – Bolivia, Ecuador, Peru, Argentina, Chile
- Ephedra antisyphilitica Berland ex C.A.Mey. – Clapweed, Erect Ephedra – Texas, Oklahoma, New Mexico, Nuevo León, Coahuila, Chihuahua
- Ephedra aphylla Forssk. – eastern Mediterranean from Libya and Cyprus to the Persian Gulf
- Ephedra × arenicola H.C.Cutler – Arizona, Utah (hybrid, E. cutleri × E. torreyana)
- Ephedra aspera Engelm. ex S.Watson – Boundary Ephedra, Pitamoreal – Texas, New Mexico, Arizona, Utah, Nevada, California, Chihuahua, Durango, Zacatecas, Sinaloa, Sonora, Baja California
- Ephedra aurantiaca Takht. & Pachom. – Caucasus, Kazakhstan, Turkmenistan
- Ephedra boelckei F.A.Roig – Argentina
- Ephedra botschantzevii Pachom. – Kazakhstan, Tuva region of Siberia
- Ephedra breana Phil. – Peru, Bolivia, Chile, Argentina
- Ephedra brevifoliata Ghahr. – Iran
- Ephedra californica S.Watson – California Ephedra, California Jointfir – California, western Arizona, Baja California
- Ephedra chilensis C.Presl – Chile, Argentina
- Ephedra compacta Rose – widespread in much of Mexico
- Ephedra coryi E.L.Reed – Cory's Ephedra – Texas, New Mexico
- Ephedra cutleri Peebles – Navajo Ephedra, Cutler's Ephedra, Cutler Mormon-tea, Cutler's Jointfir – Colorado, Utah, Arizona, New Mexico, Wyoming
- Ephedra dahurica Turcz. – Siberia, Mongolia
- Ephedra dawuensis Y.Yang – Sichuan
- Ephedra distachya L. – Joint-pine, Jointfir – southern Europe and central Asia from Portugal to Kazakhstan
- Ephedra × eleutherolepis V.A.Nikitin – Tajikistan (hybrid E. intermedia × E. strobilacea)
- Ephedra equisetina Bunge – Ma huang – Caucasus, Central Asia, Siberia, Mongolia, Gansu, Hebei, Inner Mongolia, Ningxia, Qinghai, Shanxi, Xinjiang
- Ephedra fasciculata A.Nelson – Arizona Ephedra, Arizona Jointfir, Desert Mormon-tea – Arizona, California, Nevada, Utah
- Ephedra fedtschenkoae Paulsen – Central Asia, Siberia, Mongolia, Xinjiang
- Ephedra foeminea Forssk. – North Africa, Somalia, Balkans, Italy, Middle East; naturalized in Santa Barbara County of California
- Ephedra foliata Boiss. ex C.A.Mey. – North Africa, Somalia, Middle East, India
- Ephedra fragilis Desf. – Mediterranean, Canary Islands, Madeira
- Ephedra frustillata Miers – Patagonian Ephedra – Chile, Argentina
- Ephedra funerea Coville & C.V.Morton – Death Valley Ephedra, Death Valley Jointfir – California, Arizona, Nevada
- Ephedra gerardiana Wall. ex Klotzsch & Garcke – Gerard's Jointfir, Shan Ling Ma Huang – Himalayas, Tibet, Yunnan, Siberia, Central Asia
- Ephedra gracilis Phil. ex Stapf
- Ephedra holoptera Riedl – Iran
- Ephedra intermedia Schrenk & C.A.Mey. – China, Siberia, Central Asia, Himalayas, Iran, Pakistan
- Ephedra kardangensis P.Sharma & P.L.Uniyal – western Himalayas
- Ephedra khurikensis P.Sharma & P.L.Uniyal – western Himalayas
- Ephedra laristanica Assadi – Iran
- Ephedra likiangensis Florin – Guizhou, Sichuan, Tibet, Yunnan
- Ephedra lomatolepis Schrenk – Kazakhstan, Tuva region of Siberia
- Ephedra major Host – Mediterranean, Middle East, Central Asia; from Canary Islands to Kashmir
- Ephedra milleri Freitag & Maier-St. – Oman, Yemen
- Ephedra minuta Florin – Qinghai, Sichuan
- Ephedra monosperma J.G.Gmel. ex C.A.Mey. – Siberia, Mongolia, much of China including Tibet and Xinjiang
- Ephedra multiflora Phil. ex Stapf – Chile, Argentina
- Ephedra nevadensis S.Watson – Nevada Ephedra, Nevada Jointfir, Nevada Mormon-tea – Baja California, California, Arizona, Nevada, Utah, Oregon
- Ephedra ochreata Miers – Argentina
- Ephedra oxyphylla Riedl – Afghanistan
- Ephedra pachyclada Boiss. – Middle East from Sinai and Yemen to Pakistan
- Ephedra pangiensis Rita Singh & P.Sharma
- Ephedra pedunculata Engelm. ex S.Watson – Vine Ephedra, Vine Jointfir – Texas, Chihuahua, Coahuila, Durango, San Luis Potosí, Nuevo León, Zacatecas
- Ephedra pentandra Pachom. – Iran
- Ephedra procera Fisch. & C.A.Mey. − Iran, Caucasus
- Ephedra przewalskii Stapf – Central Asia, Mongolia, Pakistan, Gansu, Inner Mongolia, Ningxia, Qinghai, Tibet
- Ephedra pseudodistachya Pachom. – Siberia, Mongolia
- Ephedra regeliana Florin – Xi Zi Ma Huang – Central Asia, Siberia, Pakistan, Xinjiang
- Ephedra rhytidosperma Pachom., syn. E. lepidosperma C.Y.Cheng – Gansu, Inner Mongolia, Ningxia, Mongolia
- Ephedra rituensis Y.Yang, D.Z.Fu & G.H.Zhu – Qinghai, Xinjiang, Tibet
- Ephedra rupestris Benth. – Ecuador, Peru, Bolivia, Argentina
- Ephedra sarcocarpa Aitch. & Hemsl. – Pakistan, Afghanistan
- Ephedra saxatilis (Stapf) Royle ex Florin
- Ephedra sinica Stapf – Cao Ma Huang, Chinese ephedra – Mongolia, Siberia, Primorye, Manchuria
- Ephedra somalensis Freitag & Maier-St. – Somalia, Eritrea
- Ephedra strobilacea Bunge – Iran, Central Asia
- Ephedra sumlingensis P.Sharma & P.L.Uniyal – western Himalayas
- Ephedra tilhoana Maire – Chad
- Ephedra torreyana S.Watson – Torrey's Ephedra, Torrey's Jointfir, Torrey's Mormon-tea, Cañutillo – Nevada, Utah, Colorado, Arizona, New Mexico, Texas, Chihuahua
- Ephedra transitoria Riedl – Iraq, Syria, Palestine, Saudi Arabia
- Ephedra triandra Tul. − Bolivia, Argentina
- Ephedra trifurca Torrey ex S.Watson – Longleaf Ephedra, Longleaf Jointfir, Longleaf Mormon-tea, Popotilla, Teposote – California, Arizona, New Mexico, Texas, Chihuahua, Sonora, Baja California
- Ephedra trifurcata Zöllner
- Ephedra tweedieana C.A.Mey. – Brazil, Argentina, Uruguay
- Ephedra viridis Coville – Green Ephedra, Green Mormon-tea – California, Nevada, Utah, Arizona, New Mexico, Colorado, Wyoming, South Dakota, Oregon
- Ephedra vvedenskyi Pachom. – Iran, Caucasus, Turkmenistan
- Ephedra yangthangensis Prabha Sharma & Rita Singh – Yangthang to Ka, Leo, Nako, Chango, Chulling, Sumdo, Hoorling and Lira of Kinnaur district of Himachal Pradesh 
The Ephedra alkaloids, ephedrine and pseudoephedrine – constituents of E. sinica and other members of the genus – have sympathomimetic and decongestant qualities,  and have been used as dietary supplements, mainly for weight loss.  The drug, ephedrine, is used to prevent low blood pressure during spinal anesthesia. 
In the United States, ephedra supplements were banned from the market in the early 21st century due to serious safety risks.  Plants of the genus Ephedra, including E. sinica and others, were used in traditional medicine for treating headache and respiratory infections, but there is no scientific evidence they are effective or safe for these purposes. 
Alkaloids obtained from the species of Ephedra used in herbal medicines, which are used to synthetically prepare pseudoephedrine and ephedrine, can cause cardiovascular events.  These events have been associated with arrhythmias, palpitations, tachycardia and myocardial infarction.  Caffeine consumption in combination with ephedrine has been reported to increase the risk of these cardiovascular events.  
Earliest uses of Ephedra spp. (mahuang) for specific illnesses date back to 5000 BC. Ephedrine and isomers were already isolated in 1881 from Ephedra dystachia and characterized by the Japanese organic chemist Nagai Nagayoshi of the 19th century. His work to access Ephedra drug materials to isolate a pure pharmaceutical substance, and the systematic production of semi-synthetic derivatives thereof is relevant still today as the three species Ephedra sinica, Ephedra vulgaris and to a lesser extent Ephedra equisetina are commercially grown in Mainland China as a source for natural ephedrines and isomers for use in pharmacy. E. sinica and E. vulgaris usually carry six optically active phenylethylamines, mostly ephedrine and pseudoephedrine with minor amounts of norephedrine, norpseudoephedrine as well as the three methylated analogs. Reliable information on the total alkaloid content of the crude drug is difficult to obtain. Based on HPLC analyses in industrial settings, the concentrations of total alkaloids in dried Herba Ephedra ranged between 1 and 4%, and in some cases up to 6%. 
For a review of the alkaloid distribution in different species of the genus Ephedra see Jian-fang Cui (1991).  Other American and European species of Ephedra, e.g. Ephedra nevadensis (Nevada Mormon tea) have not been systematically assayed; based on unpublished field investigations, they contain very low levels (less than 0.1%) or none at all. 
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|Wikimedia Commons has media related to Ephedra.|
- Ephedra viridis (Plants for a Future Database)
- Usage in Chinese Medicine
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- Ephedra - Clinical summary and mechanism of action, MSKCC Memorial Sloan Kettering Cancer Center
- Ephedraceae of Mongolia in FloraGREIF