Synaptophysin, also known as the major synaptic vesicle protein p38, is a
protein that in humans is encoded by the SYPgene.[5][6]
Genomics
The gene is located on the short arm of
X chromosome (Xp11.23-p11.22). It is 12,406 bases in length and lies on the minus strand. The encoded protein has 313 amino acids with a predicted molecular weight of 33.845
kDa.
The exact function of the protein is unknown: it interacts with the essential synaptic vesicle protein
synaptobrevin, but when the synaptophysin gene is experimentally inactivated in animals, they still develop and function normally.[8] Recent research has shown, however, that elimination of synaptophysin in mice creates behavioral changes such as increased exploratory behavior, impaired
object novelty recognition, and reduced
spatial learning.[9]
^Leong, Anthony S-Y; Cooper, Kumarason; Leong, F Joel W-M (2003). Manual of Diagnostic Cytology (2 ed.). Greenwich Medical Media, Ltd. pp. 405–406.
ISBN978-1-84110-100-2.
^Horikawa HP, Kneussel M, El Far O, Betz H (November 2002). "Interaction of synaptophysin with the AP-1 adaptor protein gamma-adaptin". Mol. Cell. Neurosci. 21 (3): 454–62.
doi:
10.1006/mcne.2002.1191.
PMID12498786.
S2CID54366866.
Kalina M, Lukinius A, Grimelius L, Höög A, Falkmer S (1991). "Ultrastructural localization of synaptophysin to the secretory granules of normal glucagon and insulin cells in human islets of Langerhans". Ultrastructural Pathology. 15 (3): 215–9.
doi:
10.3109/01913129109021883.
PMID1908157.
Goto S, Hirano A, Pearson J (1990). "Calcineurin and synaptophysin in the human spinal cord of normal individuals and patients with familial dysautonomia". Acta Neuropathol. 79 (6): 647–52.
doi:
10.1007/BF00294243.
PMID2163183.
S2CID51685991.
Zhang PJ, Rosenblum MK (1997). "Synaptophysin expression in the human spinal cord. Diagnostic implications of an immunohistochemical study". Am. J. Surg. Pathol. 20 (3): 273–6.
doi:
10.1097/00000478-199603000-00002.
PMID8772779.
Fisher SE, Ciccodicola A, Tanaka K, Curci A, Desicato S, D'urso M, Craig IW (1998). "Sequence-based exon prediction around the synaptophysin locus reveals a gene-rich area containing novel genes in human proximal Xp". Genomics. 45 (2): 340–7.
doi:
10.1006/geno.1997.4941.
hdl:11858/00-001M-0000-0012-CBE6-7.
PMID9344658.
Portela-Gomes GM, Stridsberg M, Johansson H, Grimelius L (1999). "Co-localization of synaptophysin with different neuroendocrine hormones in the human gastrointestinal tract". Histochem. Cell Biol. 111 (1): 49–54.
doi:
10.1007/s004180050332.
PMID9930883.
S2CID24958759.
Davidsson P, Gottfries J, Bogdanovic N, Ekman R, Karlsson I, Gottfries CG, Blennow K (1999). "The synaptic-vesicle-specific proteins rab3a and synaptophysin are reduced in thalamus and related cortical brain regions in schizophrenic brains". Schizophrenia Research. 40 (1): 23–9.
doi:
10.1016/S0920-9964(99)00037-7.
PMID10541003.
S2CID22059000.
Thiele C, Hannah MJ, Fahrenholz F, Huttner WB (2000). "Cholesterol binds to synaptophysin and is required for biogenesis of synaptic vesicles". Nat. Cell Biol. 2 (1): 42–9.
doi:
10.1038/71366.
PMID10620806.
S2CID2623757.
Nag TC, Wadhwa S (2001). "Differential expression of syntaxin-1 and synaptophysin in the developing and adult human retina". J. Biosci. 26 (2): 179–91.
doi:
10.1007/BF02703642.
PMID11426054.
S2CID2178765.
Roudenok V, Kühnel W (2001). "The development of synaptophysin immunoreactivity in the human sympathetic ganglia". Ann. Anat. 183 (4): 345–51.
doi:
10.1016/S0940-9602(01)80177-1.
PMID11508360.
Ulfig N, Chan WY (2003). "Expression of a kinase anchoring protein 79 and synaptophysin in the developing human red nucleus". Neurosignals. 11 (2): 95–102.
doi:
10.1159/000058546.
PMID12077483.
S2CID46792009.
Wistow G, Bernstein SL, Wyatt MK, Ray S, Behal A, Touchman JW, Bouffard G, Smith D, Peterson K (2002). "Expressed sequence tag analysis of human retina for the NEIBank Project: retbindin, an abundant, novel retinal cDNA and alternative splicing of other retina-preferred gene transcripts". Mol. Vis. 8: 196–204.
PMID12107411.