From Wikipedia, the free encyclopedia
Protein-coding gene in the species Homo sapiens
E3 ubiquitin-protein ligase SIAH2 is an
enzyme that in humans is encoded by the SIAH2
gene .
[5]
[6]
Function
This gene encodes a protein that is a member of the
seven in absentia homolog (SIAH) family. The protein is an
E3 ligase and is involved in
ubiquitination and proteasome-mediated degradation of specific proteins. The activity of this
ubiquitin ligase has been implicated in regulating cellular response to
hypoxia .
[6]
Interactions
SIAH2 has been shown to
interact with
PEG10 ,
[7]
Synaptophysin ,
[8]
PEG3
[9] and
VAV1 .
[10]
References
^
a
b
c
GRCh38: Ensembl release 89: ENSG00000181788 –
Ensembl , May 2017
^
a
b
c
GRCm38: Ensembl release 89: ENSMUSG00000036432 –
Ensembl , May 2017
^
"Human PubMed Reference:" . National Center for Biotechnology Information, U.S. National Library of Medicine .
^
"Mouse PubMed Reference:" . National Center for Biotechnology Information, U.S. National Library of Medicine .
^ Hu G, Zhang S, Vidal M, Baer JL, Xu T, Fearon ER (October 1997).
"Mammalian homologs of seven in absentia regulate DCC via the ubiquitin-proteasome pathway" . Genes & Development . 11 (20): 2701–14.
doi :
10.1101/gad.11.20.2701 .
PMC
316613 .
PMID
9334332 .
^
a
b
"Entrez Gene: SIAH2 seven in absentia homolog 2 (Drosophila)" .
^ Okabe H, Satoh S, Furukawa Y, Kato T, Hasegawa S, Nakajima Y, Yamaoka Y, Nakamura Y (June 2003). "Involvement of PEG10 in human hepatocellular carcinogenesis through interaction with SIAH1". Cancer Research . 63 (12): 3043–8.
PMID
12810624 .
^ Wheeler TC, Chin LS, Li Y, Roudabush FL, Li L (March 2002).
"Regulation of synaptophysin degradation by mammalian homologues of seven in absentia" . The Journal of Biological Chemistry . 277 (12): 10273–82.
doi :
10.1074/jbc.M107857200 .
PMID
11786535 .
^ Relaix F, Wei XJ, Li W, Pan J, Lin Y, Bowtell DD, Sassoon DA, Wu X (February 2000).
"Pw1/Peg3 is a potential cell death mediator and cooperates with Siah1a in p53-mediated apoptosis" . Proceedings of the National Academy of Sciences of the United States of America . 97 (5): 2105–10.
Bibcode :
2000PNAS...97.2105R .
doi :
10.1073/pnas.040378897 .
PMC
15761 .
PMID
10681424 .
^ Germani A, Romero F, Houlard M, Camonis J, Gisselbrecht S, Fischer S, Varin-Blank N (May 1999).
"hSiah2 is a new Vav binding protein which inhibits Vav-mediated signaling pathways" . Molecular and Cellular Biology . 19 (5): 3798–807.
doi :
10.1128/mcb.19.5.3798 .
PMC
84217 .
PMID
10207103 .
Further reading
Maruyama K, Sugano S (January 1994). "Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides". Gene . 138 (1–2): 171–4.
doi :
10.1016/0378-1119(94)90802-8 .
PMID
8125298 .
Bonaldo MF, Lennon G, Soares MB (September 1996).
"Normalization and subtraction: two approaches to facilitate gene discovery" . Genome Research . 6 (9): 791–806.
doi :
10.1101/gr.6.9.791 .
PMID
8889548 .
Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K, Suyama A, Sugano S (October 1997). "Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library". Gene . 200 (1–2): 149–56.
doi :
10.1016/S0378-1119(97)00411-3 .
PMID
9373149 .
Hu G, Chung YL, Glover T, Valentine V, Look AT, Fearon ER (November 1997).
"Characterization of human homologs of the Drosophila seven in absentia (sina) gene" . Genomics . 46 (1): 103–11.
doi :
10.1006/geno.1997.4997 .
PMID
9403064 .
Hu G, Fearon ER (January 1999).
"Siah-1 N-terminal RING domain is required for proteolysis function, and C-terminal sequences regulate oligomerization and binding to target proteins" . Molecular and Cellular Biology . 19 (1): 724–32.
doi :
10.1128/mcb.19.1.724 .
PMC
83929 .
PMID
9858595 .
Germani A, Romero F, Houlard M, Camonis J, Gisselbrecht S, Fischer S, Varin-Blank N (May 1999).
"hSiah2 is a new Vav binding protein which inhibits Vav-mediated signaling pathways" . Molecular and Cellular Biology . 19 (5): 3798–807.
doi :
10.1128/mcb.19.5.3798 .
PMC
84217 .
PMID
10207103 .
Relaix F, Wei XJ, Li W, Pan J, Lin Y, Bowtell DD, Sassoon DA, Wu X (February 2000).
"Pw1/Peg3 is a potential cell death mediator and cooperates with Siah1a in p53-mediated apoptosis" . Proceedings of the National Academy of Sciences of the United States of America . 97 (5): 2105–10.
Bibcode :
2000PNAS...97.2105R .
doi :
10.1073/pnas.040378897 .
PMC
15761 .
PMID
10681424 .
Joensuu T, Hämäläinen R, Lehesjoki AE, de la Chapelle A, Sankila EM (February 2000). "A sequence-ready map of the Usher syndrome type III critical region on chromosome 3q". Genomics . 63 (3): 409–16.
doi :
10.1006/geno.1999.6096 .
PMID
10704288 .
Matsuzawa SI, Reed JC (May 2001).
"Siah-1, SIP, and Ebi collaborate in a novel pathway for beta-catenin degradation linked to p53 responses" . Molecular Cell . 7 (5): 915–26.
doi :
10.1016/S1097-2765(01)00242-8 .
PMID
11389839 .
Boehm J, He Y, Greiner A, Staudt L, Wirth T (August 2001).
"Regulation of BOB.1/OBF.1 stability by SIAH" . The EMBO Journal . 20 (15): 4153–62.
doi :
10.1093/emboj/20.15.4153 .
PMC
149152 .
PMID
11483518 .
Wheeler TC, Chin LS, Li Y, Roudabush FL, Li L (March 2002).
"Regulation of synaptophysin degradation by mammalian homologues of seven in absentia" . The Journal of Biological Chemistry . 277 (12): 10273–82.
doi :
10.1074/jbc.M107857200 .
PMID
11786535 .
Kutsenko AS, Gizatullin RZ, Al-Amin AN, Wang F, Kvasha SM, Podowski RM, Matushkin YG, Gyanchandani A, Muravenko OV, Levitsky VG, Kolchanov NA, Protopopov AI, Kashuba VI, Kisselev LL, Wasserman W, Wahlestedt C, Zabarovsky ER (July 2002).
"NotI flanking sequences: a tool for gene discovery and verification of the human genome" . Nucleic Acids Research . 30 (14): 3163–70.
doi :
10.1093/nar/gkf428 .
PMC
135748 .
PMID
12136098 .
Habelhah H, Frew IJ, Laine A, Janes PW, Relaix F, Sassoon D, Bowtell DD, Ronai Z (November 2002).
"Stress-induced decrease in TRAF2 stability is mediated by Siah2" . The EMBO Journal . 21 (21): 5756–65.
doi :
10.1093/emboj/cdf576 .
PMC
131073 .
PMID
12411493 .
Okabe H, Satoh S, Furukawa Y, Kato T, Hasegawa S, Nakajima Y, Yamaoka Y, Nakamura Y (June 2003). "Involvement of PEG10 in human hepatocellular carcinogenesis through interaction with SIAH1". Cancer Research . 63 (12): 3043–8.
PMID
12810624 .
Fanelli M, Fantozzi A, De Luca P, Caprodossi S, Matsuzawa S, Lazar MA, Pelicci PG, Minucci S (February 2004).
"The coiled-coil domain is the structural determinant for mammalian homologues of Drosophila Sina-mediated degradation of promyelocytic leukemia protein and other tripartite motif proteins by the proteasome" . The Journal of Biological Chemistry . 279 (7): 5374–9.
doi :
10.1074/jbc.M306407200 .
PMID
14645235 .
Germani A, Prabel A, Mourah S, Podgorniak MP, Di Carlo A, Ehrlich R, Gisselbrecht S, Varin-Blank N, Calvo F, Bruzzoni-Giovanelli H (December 2003).
"SIAH-1 interacts with CtIP and promotes its degradation by the proteasome pathway" . Oncogene . 22 (55): 8845–51.
doi :
10.1038/sj.onc.1206994 .
PMID
14654780 .
Nakayama K, Frew IJ, Hagensen M, Skals M, Habelhah H, Bhoumik A, Kadoya T, Erdjument-Bromage H, Tempst P, Frappell PB, Bowtell DD, Ronai Z (June 2004).
"Siah2 regulates stability of prolyl-hydroxylases, controls HIF1alpha abundance, and modulates physiological responses to hypoxia" . Cell . 117 (7): 941–52.
doi :
10.1016/j.cell.2004.06.001 .
PMID
15210114 .
S2CID
1447980 .