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Class of enzymes which transfer a sulfo group (–SO3) between molecules
In
biochemistry, sulfotransferases (SULTs) are
transferase
enzymes that
catalyze the transfer of a
sulfo group (R−SO−3) from a donor molecule to an acceptor
alcohol (R−OH) or
amine (R−NH2).
[1] The most common sulfo group donor is
3'-phosphoadenosine-5'-phosphosulfate (PAPS). In the case of alcohol as acceptor, the product is a
sulfate (R−OSO−3):
whereas an amine leads to a
sulfamate (R−NH−SO−3):
Both reactive groups for a
sulfonation via sulfotransferases may be part of a
protein,
lipid,
carbohydrate or
steroid.
[2]
Examples
The following are examples of sulfotransferases:
-
carbohydrate sulfotransferase:
CHST1,
CHST2,
CHST3,
CHST4,
CHST5,
CHST6,
CHST7,
CHST8,
CHST9,
CHST10,
CHST11,
CHST12,
CHST13,
CHST14
-
galactose-3-O-sulfotransferase:
GAL3ST1,
GAL3ST2,
GAL3ST3,
GAL3ST4
-
heparan sulfate 2-O-sulfotransferase:
HS2ST1
-
heparan sulfate 3-O-sulfotransferase:
HS3ST1,
HS3ST2,
HS3ST3A1,
HS3ST3B1,
HS3ST4,
HS3ST5,
HS3ST6
-
heparan sulfate 6-O-sulfotransferase:
HS6ST1,
HS6ST2,
HS6ST3
-
N-deacetylase/N-sulfotransferase:
NDST1,
NDST2,
NDST3,
NDST4
-
tyrosylprotein sulfotransferase:
TPST1,
TPST2
-
uronyl-2-sulfotransferase
-
Estrone sulfotransferase
-
Chondroitin 4-sulfotransferase
- other:
SULT1A1,
SULT1A2,
SULT1A3,
SULT1A4,
SULT1B1,
SULT1C2,
SULT1C3,
SULT1C4,
SULT1D1P,
SULT1E1,
SULT2A1,
SULT2B1,
SULT4A1,
SULT6B1
See also
References
External links
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