From Wikipedia, the free encyclopedia
Canadian-British scientist (1957–)
Randy John Read
FRS
[9] (born 9 June 1957)
[4] is a
Wellcome Trust Principal Research Fellow and professor of
protein crystallography at the
University of Cambridge .
[1]
[10]
[11]
[12]
Education
Read was educated at the
University of Alberta in Edmonton, Canada where he was awarded a Bachelor of Science degree in 1979 followed by a PhD in 1986
[4] for
X-ray crystallography of
serine proteases and their protein inhibitors supervised by
Michael N. G. James .
[2]
[3]
Career and research
Following his PhD, Read was appointed
assistant professor from 1988 to 1993 and
associate professor from 1993 to 1998 at the University of Alberta.
[4] As of 2017
[update] , Read's research interests are in
protein
crystallography and
maximum likelihood estimation .
[1] His research has been published in leading
peer reviewed
scientific journals including
Nature ,
[13]
[14]
[15]
Science ,
[16] the
Journal of Applied Crystallography
[5]
Acta Crystallographica ,
[7]
[17]
[18]
Structure ,
[19]
[20]
PNAS ,
[21] the
Journal of Molecular Biology
[22]
[23] and the
Journal of Clinical Endocrinology and Metabolism .
[24]
Awards and honours
Read was elected
Fellow of the Royal Society (FRS) in 2014. His nomination reads:
Professor Read is known internationally for his outstanding and fundamental contributions to the development of
macromolecular crystallographic software. His application of maximum likelihood based
algorithms to the solution of macromolecular crystal structures by
molecular replacement (a technique that uses a known structure of a homologue to solve an unknown structure) has resulted in software (Phaser) that is foremost in the field. He also devised and demonstrated an improved likelihood target function for model refinement that has been adopted by all major refinement programs. In addition, Professor Read has led
structural work that has made significant contributions to understanding the mechanisms of proteins relevant to disease (
bacterial toxins and
serpins ).
[9]
References
^
a
b
c
Randy Read publications indexed by
Google Scholar
^
a
b Fujinaga, Masao; Sielecki, Anita R.; Read, Randy J.; Ardelt, Wojciech; Laskowski, Michael; James, Michael N.G. (1987). "Crystal and molecular structures of the complex of α-chymotrypsin with its inhibitor Turkey ovomucoid third domain at 1.8 Å resolution".
Journal of Molecular Biology . 195 (2): 397–418.
doi :
10.1016/0022-2836(87)90659-0 .
ISSN
0022-2836 .
PMID
3477645 .
^
a
b
Read, Randy John (1986). X-ray crystallographic studies on serine proteinases and their protein inhibitors (PhD thesis).
doi :
10.7939/R33776175 .
hdl :
10402/era.3098 .
ProQuest
250072156 .
^
a
b
c
d Anon (2014).
"Read, Prof. Randy John" .
Who's Who (online
Oxford University Press ed.). A & C Black.
doi :
10.1093/ww/9780199540884.013.43034 . (Subscription or
UK public library membership required.)
^
a
b McCoy, A. J.; Grosse-Kunstleve, R. W.; Adams, P. D.; Winn, M. D.; Storoni, L. C.;
Read, R. J. (2007).
"Phaser crystallographic software" . Journal of Applied Crystallography . 40 (4): 658–674.
Bibcode :
2007JApCr..40..658M .
CiteSeerX
10.1.1.322.8550 .
doi :
10.1107/S0021889807021206 .
PMC
2483472 .
PMID
19461840 .
^ Adams, P. D.; Grosse-Kunstleve, R. W.; Hung, L. W.; Ioerger, T. R.; McCoy, A. J.; Moriarty, N. W.; Read, R. J.; Sacchettini, J. C.; Sauter, N. K.; Terwilliger, T. C. (2002).
"PHENIX: Building new software for automated crystallographic structure determination" . Acta Crystallographica Section D . 58 (11): 1948–1954.
Bibcode :
2002AcCrD..58.1948A .
doi :
10.1107/S0907444902016657 .
hdl :
1969.1/180215 .
PMID
12393927 .
^
a
b Adams, P. D.; Afonine, P. V.; Bunkóczi, G. B.; Chen, V. B.; Davis, I. W.; Echols, N.; Headd, J. J.; Hung, L. W.; Kapral, G. J.; Grosse-Kunstleve, R. W.; McCoy, A. J.; Moriarty, N. W.; Oeffner, R.; Read, R. J.; Richardson, D. C.; Richardson, J. S.; Terwilliger, T. C.; Zwart, P. H. (2010).
"PHENIX: A comprehensive Python-based system for macromolecular structure solution" . Acta Crystallographica Section D . 66 (2): 213–21.
Bibcode :
2010AcCrD..66..213A .
doi :
10.1107/S0907444909052925 .
PMC
2815670 .
PMID
20124702 .
^ Liebschner, Dorothee; Afonine, Pavel V.; Baker, Matthew L.; Bunkóczi, Gábor; Chen, Vincent B.; Croll, Tristan I.; Hintze, Bradley; Hung, Li-Wei; Jain, Swati; McCoy, Airlie J.; Moriarty, Nigel W.; Oeffner, Robert D.; Poon, Billy K.; Prisant, Michael G.; Read, Randy J. (1 October 2019).
"Macromolecular structure determination using X-rays, neutrons and electrons: recent developments in Phenix" . Acta Crystallographica Section D: Structural Biology . 75 (10): 861–877.
Bibcode :
2019AcCrD..75..861L .
doi :
10.1107/S2059798319011471 .
ISSN
2059-7983 .
PMC
6778852 .
PMID
31588918 .
^
a
b Anon (2014).
"Professor Randy Read FRS" . London: royalsociety.org. Archived from
the original on 5 August 2014.
^
Randy Read publications indexed by the
Scopus bibliographic database. (subscription required)
^ Read, Randy (2017).
"Randy Read's Homepage" . University of Cambridge. Archived from
the original on 15 May 2013. [
dead link ]
^
Randy Read publications from
Europe PubMed Central
^ Zhou, A.; Carrell, R. W.; Murphy, M. P.; Wei, Z.; Yan, Y.; Stanley, P. L. D.; Stein, P. E.; Pipkin, F. B.; Read, R. J. (2010).
"A redox switch in angiotensinogen modulates angiotensin release" . Nature . 468 (7320): 108–11.
Bibcode :
2010Natur.468..108Z .
doi :
10.1038/nature09505 .
PMC
3024006 .
PMID
20927107 .
^ Dimaio, F.; Terwilliger, T. C.;
Read, R. J. ; Wlodawer, A.; Oberdorfer, G.; Wagner, U.; Valkov, E.; Alon, A.; Fass, D.; Axelrod, H. L.; Das, D.; Vorobiev, S. M.; Iwaï, H.; Pokkuluri, P. R.;
Baker, D. (2011).
"Improved molecular replacement by density- and energy-guided protein structure optimization" . Nature . 473 (7348): 540–3.
Bibcode :
2011Natur.473..540D .
doi :
10.1038/nature09964 .
PMC
3365536 .
PMID
21532589 .
^ Qian, B.; Raman, S.; Das, R.; Bradley, P.; McCoy, A. J.;
Read, R. J. ;
Baker, D. (2007).
"High-resolution structure prediction and the crystallographic phase problem" . Nature . 450 (7167): 259–64.
Bibcode :
2007Natur.450..259Q .
doi :
10.1038/nature06249 .
PMC
2504711 .
PMID
17934447 .
^ Jackson, R. N.; Golden, S. M.; Van Erp, P. B.; Carter, J; Westra, E. R.; Brouns, S. J.; Van Der Oost, J; Terwilliger, T. C.; Read, R. J.; Wiedenheft, B (2014).
"Structural biology. Crystal structure of the CRISPR RNA-guided surveillance complex from Escherichia coli" . Science . 345 (6203): 1473–9.
doi :
10.1126/science.1256328 .
PMC
4188430 .
PMID
25103409 .
^ Brünger, A. T.; Adams, P. D.; Clore, G. M.; Delano, W. L.; Gros, P.; Grosse-Kunstleve, R. W.; Jiang, J. S.; Kuszewski, J.; Nilges, M.; Pannu, N. S.; Read, R. J.; Rice, L. M.; Simonson, T.; Warren, G. L. (1998). "Crystallography & NMR System: A New Software Suite for Macromolecular Structure Determination". Acta Crystallographica Section D . 54 (5): 905–21.
Bibcode :
1998AcCrD..54..905B .
doi :
10.1107/S0907444998003254 .
PMID
9757107 .
S2CID
33910776 .
^
Read, R. J. ;
Kleywegt, G. J. (2009).
"Case-controlled structure validation" . Acta Crystallographica Section D . 65 (Pt 2): 140–7.
Bibcode :
2009AcCrD..65..140R .
doi :
10.1107/S0907444908041085 .
PMC
2631636 .
PMID
19171969 .
^ Read, R. J.; Adams, P. D.; Arendall Wb, 3rd; Brunger, A. T.; Emsley, P; Joosten, R. P.; Kleywegt, G. J.; Krissinel, E. B.; Lütteke, T; Otwinowski, Z; Perrakis, A; Richardson, J. S.; Sheffler, W. H.; Smith, J. L.; Tickle, I. J.; Vriend, G; Zwart, P. H. (2011).
"A new generation of crystallographic validation tools for the protein data bank" . Structure . 19 (10): 1395–412.
doi :
10.1016/j.str.2011.08.006 .
PMC
3195755 .
PMID
22000512 . {{
cite journal }}
: CS1 maint: numeric names: authors list (
link )
^
Kleywegt, G. J. ;
Read, R. J. (1997).
"Not your average density" .
Structure . 5 (12): 1557–69.
doi :
10.1016/s0969-2126(97)00305-5 .
PMID
9438862 .
^ Deane, J. E.; Graham, S. C.; Kim, N. N.; Stein, P. E.; McNair, R; Cachón-González, M. B.; Cox, T. M.; Read, R. J. (2011).
"Insights into Krabbe disease from structures of galactocerebrosidase" . Proceedings of the National Academy of Sciences . 108 (37): 15169–73.
doi :
10.1073/pnas.1105639108 .
PMC
3174575 .
PMID
21876145 .
^ Zhou, A; Wei, Z; Stanley, P. L.; Read, R. J.; Stein, P. E.; Carrell, R. W. (2008).
"The S-to-R transition of corticosteroid-binding globulin and the mechanism of hormone release" . Journal of Molecular Biology . 380 (1): 244–51.
doi :
10.1016/j.jmb.2008.05.012 .
PMID
18513745 .
^ Stoop, A. A.; Eldering, E; Dafforn, T. R.; Read, R. J.; Pannekoek, H (2001).
"Different structural requirements for plasminogen activator inhibitor 1 (PAI-1) during latency transition and proteinase inhibition as evidenced by phage-displayed hypermutated PAI-1 libraries" . Journal of Molecular Biology . 305 (4): 773–83.
doi :
10.1006/jmbi.2000.4356 .
PMID
11162091 .
Archived from the original on 6 May 2022. Retrieved 6 May 2022 .
^ Chan, W. L.; Carrell, R. W.; Zhou, A; Read, R. J. (2013).
"How changes in affinity of corticosteroid-binding globulin modulate free cortisol concentration" . The Journal of Clinical Endocrinology & Metabolism . 98 (8): 3315–22.
doi :
10.1210/jc.2012-4280 .
PMC
3813945 .
PMID
23783094 .
International National Academics Other