Keightley leads a laboratory which works on evolutionary genetics and the evolutionary impact of new mutations on molecular genetic and quantitative trait variation and fitness. His research investigates genetic variation and adaptation through the analysis of nucleotide variation within natural populations and between different species.[5][6][7][8][9][10][11][12]
Keightley was elected a Fellow of the
Royal Society in 2014. His nomination reads:
Peter Keightley is a leading evolutionary geneticist. He has made seminal contributions to the
genetics and
evolution of quantitative
traits, and to
molecular evolution and variation. His work combines theoretical modelling, genetic experimentation and
bioinformatic studies of
DNA sequences, in an unusually productive and innovative way. His work has shed light on several fundamental questions in genetics and evolution. He is especially well known for his work on the effects on
fitness and rate of occurrence of spontaneous
mutations. This has led to a much improved estimate of the deleterious mutation rate for the
genome as a whole.[1]
^Drosophila 12 Genomes, Consortium; Clark, A. G.;
Eisen, M. B.; Smith, D. R.; Bergman, C. M.; Oliver, B; Markow, T. A.; Kaufman, T. C.;
Kellis, M; Gelbart, W; Iyer, V. N.; Pollard, D. A.; Sackton, T. B.; Larracuente, A. M.; Singh, N. D.; Abad, J. P.; Abt, D. N.; Adryan, B; Aguade, M; Akashi, H; Anderson, W. W.; Aquadro, C. F.; Ardell, D. H.; Arguello, R; Artieri, C. G.; Barbash, D. A.; Barker, D; Barsanti, P; Batterham, P; et al. (2007).
"Evolution of genes and genomes on the Drosophila phylogeny". Nature. 450 (7167): 203–18.
Bibcode:
2007Natur.450..203C.
doi:10.1038/nature06341.
PMID17994087.{{
cite journal}}: CS1 maint: numeric names: authors list (
link)