From Wikipedia, the free encyclopedia
Class of enzymes
Protein-synthesizing GTPases (
EC
3.6.5.3 , elongation factor (EF) , initiation factor (IF) , peptide-release or termination factor ) are enzymes involved in mRNA translation into protein by the ribosome, with
systematic name GTP phosphohydrolase (mRNA-translation-assisting) .
[1]
[2]
[3]
[4]
[5] They usually include
translation initiation factors such as
IF-2 and
translation elongation factors such as
EF-Tu .
References
^ Kurzchalia TV, Bommer UA, Babkina GT, Karpova GG (October 1984).
"GTP interacts with the gamma-subunit of eukaryotic initiation factor eIF-2" . FEBS Letters . 175 (2): 313–6.
doi :
10.1016/0014-5793(84)80758-9 .
PMID
6566615 .
^ Kisselev LL (1995). "Termination of translation in eukaryotes". Biochemistry and Cell Biology . 73 (11–12): 1079–86.
doi :
10.1139/o95-116 .
PMID
8722024 .
^ Rodnina MV, Savelsbergh A, Katunin VI, Wintermeyer W (January 1997). "Hydrolysis of GTP by elongation factor G drives tRNA movement on the ribosome". Nature . 385 (6611): 37–41.
doi :
10.1038/385037a0 .
PMID
8985244 .
^ Freistroffer DV, Pavlov MY, MacDougall J, Buckingham RH, Ehrenberg M (July 1997).
"Release factor RF3 in E.coli accelerates the dissociation of release factors RF1 and RF2 from the ribosome in a GTP-dependent manner" . The EMBO Journal . 16 (13): 4126–33.
doi :
10.1093/emboj/16.13.4126 .
PMC
1170035 .
PMID
9233821 .
^ Krab IM, Parmeggiani A (November 1998). "EF-Tu, a GTPase odyssey". Biochimica et Biophysica Acta (BBA) - Gene Structure and Expression . 1443 (1–2): 1–22.
doi :
10.1016/s0167-4781(98)00169-9 .
PMID
9838020 .
External links
Activity Regulation Classification Kinetics Types