From Wikipedia, the free encyclopedia
InterPro Family
G12/G13 alpha subunits are
alpha subunits of
heterotrimeric G proteins that link cell surface
G protein-coupled receptors primarily to
guanine nucleotide exchange factors for the
Rho
small GTPases to regulate the
actin
cytoskeleton.
[1] Together, these two proteins comprise one of the four classes of G protein alpha subunits.
[2] G protein alpha subunits bind to guanine nucleotides and function in a regulatory cycle, and are active when bound to
GTP but inactive and associated with the
G beta-gamma complex when bound to
GDP.
[3]
[4] G12/G13 are not targets of
pertussis toxin or
cholera toxin, as are other classes of G protein alpha subunits.
[5]
G proteins G12 and G13 regulate actin cytoskeletal remodeling in cells during movement and migration, including
cancer cell
metastasis.
[6] G13 is also essential for
receptor tyrosine kinase-induced
migration of
fibroblast and
endothelial cells.
[7]
Genes
See also
References
-
^ Dhanasekaran N, Dermott JM (1996). "Signaling by the G12 class of G proteins". Cell. Signal. 8 (4): 235–45.
doi:
10.1016/0898-6568(96)00048-4.
PMID
8842523.
-
^ Strathmann MP, Simon MI (1991).
"G alpha 12 and G alpha 13 subunits define a fourth class of G protein alpha subunits". Proc. Natl. Acad. Sci. U.S.A. 88 (13): 5582–6.
Bibcode:
1991PNAS...88.5582S.
doi:
10.1073/pnas.88.13.5582.
PMC
51921.
PMID
1905812.
-
^ Gilman AG (1987). "G proteins: transducers of receptor-generated signals". Annual Review of Biochemistry. 56: 615–649.
doi:
10.1146/annurev.bi.56.070187.003151.
PMID
3113327.
-
^ Rodbell M (1995).
"Nobel Lecture: Signal transduction: Evolution of an idea". Bioscience Reports. 15 (3): 117–133.
doi:
10.1007/bf01207453.
PMC
1519115.
PMID
7579038.
S2CID
11025853.
-
^ Harhammer R, Nürnberg B, Harteneck C, Leopoldt D, Exner T, Schultz G (1996).
"Distinct biochemical properties of the native members of the G12 G-protein subfamily. Characterization of G alpha 12 purified from rat brain". Biochem. J. 319. ( Pt 1) (Pt 1): 165–71.
doi:
10.1042/bj3190165.
PMC
1217750.
PMID
8870664.
-
^ Wang D, Tan YC, Kreitzer GE, Nakai Y, Shan D, Zheng Y, Huang XY (2006).
"G proteins G12 and G13 control the dynamic turnover of growth factor-induced dorsal ruffles". J. Biol. Chem. 281 (43): 32660–7.
doi:
10.1074/jbc.M604588200.
PMID
16943201.
-
^ Shan D, Chen L, Wang D, Tan YC, Gu JL, Huang XY (2006).
"The G protein G alpha(13) is required for growth factor-induced cell migration". Dev. Cell. 10 (6): 707–18.
doi:
10.1016/j.devcel.2006.03.014.
PMID
16740474.
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