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Names | |||
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IUPAC name
Nitrosourea
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Identifiers | |||
3D model (
JSmol)
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ChemSpider | |||
PubChem
CID
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UNII | |||
CompTox Dashboard (
EPA)
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Properties | |||
CH3N3O2 | |||
Molar mass | 89.054 g·mol−1 | ||
Except where otherwise noted, data are given for materials in their
standard state (at 25 °C [77 °F], 100 kPa).
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Nitrosourea is both the name of a molecule, and a class of compounds that include a nitroso (R-NO) group and a urea.
Examples include:
Nitrosourea compounds are DNA alkylating agents and are often used in chemotherapy. [1] They are lipophilic and thus can cross the blood–brain barrier, making them useful in the treatment of brain tumors such as glioblastoma multiforme. [2]
Some nitrosoureas (e.g. lomustine) have been associated with the development of interstitial lung disease. [3]