From Wikipedia, the free encyclopedia
Chemical compound
Losoxantrone
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7-Hydroxy-2-{2-[(2-hydroxyethyl)amino]ethyl}-5-({2-[(2-hydroxyethyl)amino]ethyl}amino)dibenzo[cd,g]indazol-6(2H)-one
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Formula | C22H27N5O4 |
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Molar mass | 425.489 g·mol−1 |
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3D model (
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c1cc-2c(c(c1)O)C(=O)c3c(ccc4c3c2nn4CCNCCO)NCCNCCO
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InChI=InChI=1S/C22H27N5O4/c28-12-9-23-6-7-25-15-4-5-16-20-19(15)22(31)18-14(2-1-3-17(18)30)21(20)26-27(16)11-8-24-10-13-29/h1-5,23-25,28-30H,6-13H2 YKey:YROQEQPFUCPDCP-UHFFFAOYSA-N Y
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Losoxantrone (biantrazole) is an
anthroquinone
anthrapyrazole
antineoplastic agent and
analog of
mitoxantrone.
[1]
[2] It is also sometimes known as DuP 941.
[3]
See also
References
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^ Showalter HD, Johnson JL, Hoftiezer JM, Turner WR, Werbel LM, Leopold WR, et al. (January 1987). "Anthrapyrazole anticancer agents. Synthesis and structure-activity relationships against murine leukemias". Journal of Medicinal Chemistry. 30 (1): 121–31.
doi:
10.1021/jm00384a021.
PMID
3806589.
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^ Beylin VG, Colbry NL, Goel OP, Haky JE, Johnson DR, Johnson JL, Kanter GD, Leeds RL, Leja B, Lewis EP, Rithner CD (1989). "Anticancer anthrapyrazoles. Improved syntheses of clinical agents CI-937, CI-941, and piroxantrone hydrochloride". Journal of Heterocyclic Chemistry. 26: 85–96.
doi:
10.1002/jhet.5570260117.
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^ Leteurtre F, Kohlhagen G, Paull KD, Pommier Y (August 1994).
"Topoisomerase II inhibition and cytotoxicity of the anthrapyrazoles DuP 937 and DuP 941 (Losoxantrone) in the National Cancer Institute preclinical antitumor drug discovery screen". Journal of the National Cancer Institute. 86 (16): 1239–44.
doi:
10.1093/jnci/86.16.1239.
PMID
8040892.