In molecular biology mir-451 microRNA is a short
RNA molecule.
MicroRNAs function to regulate the expression levels of other genes by several mechanisms.
miR-451 regulates the drug-transporter protein
P-glycoprotein, potentially promoting resistance to the chemotherapy drug
Paclitaxel.[1]
Applications
A
proof-of-concept experiment has shown that miR-451, as well as
mir-126 and
mir-150, could be using in
forensic science to distinguish between
blood and
saliva samples.[2] This is made possible by different miRNA profiles of miRNAs in the different tissue types.[2]
References
^van Jaarsveld, MT; Helleman, J; Berns, EM; Wiemer, EA (August 2010). "MicroRNAs in ovarian cancer biology and therapy resistance". The International Journal of Biochemistry & Cell Biology. 42 (8): 1282–1290.
doi:
10.1016/j.biocel.2010.01.014.
PMID20083225.
^
abCourts, C; Madea, B (Aug 9, 2011). "Specific Micro-RNA Signatures for the Detection of Saliva and Blood in Forensic Body-fluid Identification". Journal of Forensic Sciences. 56 (6): 1464–1470.
doi:
10.1111/j.1556-4029.2011.01894.x.
PMID21827476.
S2CID41948164.
Svasti S, Masaki S, Penglong T, Abe Y, Winichagoon P, Fucharoen S, Umemura T (2010). "Expression of microRNA-451 in normal and thalassemic erythropoiesis". Ann Hematol. 89 (10): 953–958.
doi:
10.1007/s00277-010-0980-7.
PMID20461517.
S2CID35296680.