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This is a list of the Los Premios MTV Latinoamérica winners and nominees for Song of the Year.
| Year | Winner | Other nominees |
|---|---|---|
| 2006 | Shakira — " Hips Don't Lie (featuring Wyclef Jean)" |
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| 2007 | Avril Lavigne — " Girlfriend" |
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| 2008 | Tokio Hotel — " Monsoon" | |
| 2009 | Lady Gaga — " Poker Face" |
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