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This is a list of the Los Premios MTV Latinoamérica winners and nominees for Best Artist — South.
| Year | Winner | Other nominees |
|---|---|---|
| 2002 | Diego Torres | |
| 2003 | Bersuit Vergarabat | |
| 2004 | Diego Torres | |
| 2005 | Miranda! | |
| 2006 | Gustavo Cerati |
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| 2007 | Airbag | |
| 2008 | Miranda! |
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| 2009 | Miranda! |
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