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This is a list of the Los Premios MTV Latinoamérica winners and nominees for Best Solo Artist.
| Year | Winner | Other nominees |
|---|---|---|
| 2002 | Best Male Artist: Juanes | |
| Best Female Artist: Shakira | ||
| 2003 | Natalia Lafourcade | |
| 2004 | Julieta Venegas | |
| 2005 | Best Male Artist: Juanes | |
| Best Female Artist: Shakira | ||
| 2006 | Julieta Venegas | |
| 2007 | Belinda | |
| 2008 | Juanes |
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| 2009 | Paulina Rubio |