Professor Emeritus of Anatomy and Molecular Biology
For other people called John White, see
John White .
John Graham White
FRS
[7] (born 1943)
[3] is an
Emeritus Professor of
Anatomy and
Molecular Biology
[3]
[2]
[8] at the
University of Wisconsin–Madison .
[9]
[10]
[11] His research interests are in the biology of the
model organism
Caenorhabditis elegans and
laser microscopy .
[12]
Education
White was educated at
Brunel University , where he was awarded an undergraduate degree in Physics in 1969.
[3] He went on to study for his PhD
[13] at University of Cambridge in 1975 for work on computer-aided reconstruction of the
nervous system of
Caenorhabditis elegans supervised by
Sydney Brenner .
[3]
Research and career
After working at the
Laboratory of Molecular Biology , White moved to the
University of Wisconsin–Madison in 1993.
[3] White's research investigates
cell division in the
nematode
Caenorhabditis elegans .
[14]
[15]
[16]
[17]
[18] With collaborators
Sydney Brenner ,
[19]
[20]
John Sulston
[21] and others, White co-developed
confocal microscopy and mapped the complete nervous system of
Caenorhabditis elegans , consisting of 302
neurons and over 7000
synapses . The study was published in 1986 by the
Philosophical Transactions of the Royal Society ,
[20] and is considered[
by whom? ] to be the first work in the emerging field of
connectomes . More recently his research used:
two collaborative but distinct laboratories, one a biological laboratory that investigates cell division in the nematode Caenorhabditis elegans, and the other an interdisciplinary Biophotonics Instrumentation laboratory that develops new computational and optical techniques for live cell studies.
[2]
White identified the first
gene with a demonstrated role in determining synaptic specificity. He studied the role of cell–cell interaction in determining the lineage pattern, stimulating a wide field of research. In more recent work, White and his co-workers partially confirmed his earlier model of
cytokinesis ; they discovered genes controlling cytokinesis and found features previously thought specific to plant cell division. Recognising the potentialities of laser-scanning confocal microscopy, White built a prototype microscope: with
Brad Amos he developed this into a commercially produced instrument now widely used.
[7] His former doctoral students include
Richard Durbin ,
[4] other notable former students include
Ahna Skop, Julie Ahringer
[5] and
Tony Hyman .
[6]
Awards and honours
White was the recipient of the
Mullard Award in 1994. He was elected a member of the
European Molecular Biology Organization (EMBO) in 1994
[1] and a
Fellow of the Royal Society (FRS) in 2005 .
[7]
The Center for Quantitative Cell Imaging at the University of Wisconsin-Madison hosts a biennial seminar series named in honor of John White. Featured speakers have included:
Personal life
White has been professor
emeritus since he retired in 2008.
[3]
References
^
a
b Anon (1994).
"John G. White" . people.embo.org .
^
a
b
c
"White, John - UW-Engineering Directory, College of Engineering @ The University of Wisconsin-Madison" . Archived from
the original on 9 December 2013.
^
a
b
c
d
e
f
g
h
i White, J. G. (2013).
"Getting into the mind of a worm—a personal view" .
WormBook : 1–10.
doi :
10.1895/wormbook.1.158.1 .
PMC
4781474 .
PMID
23801597 .
^
a
b
Durbin, Richard Michael (1987).
Studies on the development and organisation of the nervous system of Caenorhabditis elegans (PhD thesis). University of Cambridge.
EThOS
uk.bl.ethos.233920 .
^
a
b Malone, C. J.; Misner, L.; Le Bot, N.; Tsai, M. C.; Campbell, J. M.; Ahringer, J.; White, J. G. (2003).
"The C. Elegans hook protein, ZYG-12, mediates the essential attachment between the centrosome and nucleus" . Cell . 115 (7): 825–836.
doi :
10.1016/S0092-8674(03)00985-1 .
PMID
14697201 .
S2CID
2605372 .
^
a
b Anon (2022).
"Anthony Hyman: Group Leader" . mpi-cbg.de .
Max Planck Institute of Molecular Cell Biology and Genetics .
^
a
b
c Anon (2005).
"Dr John White FRS" . London: royalsociety.org. Archived from
the original on 17 November 2015. One or more of the preceding sentences incorporates text from the royalsociety.org website where: "All text published under the heading 'Biography' on Fellow profile pages is available under
Creative Commons Attribution 4.0 International License ." --
"Royal Society Terms, conditions and policies" . Archived from the original on 25 September 2015. Retrieved 9 March 2016 . {{
cite web }}
: CS1 maint: bot: original URL status unknown (
link )
^
John G. White publications indexed by the
Scopus bibliographic database. (subscription required)
^ Squirrell, J. M.; Wokosin, D. L.; White, J. G.; Bavister, B. D. (1999).
"Long-term two-photon fluorescence imaging of mammalian embryos without compromising viability" . Nature Biotechnology . 17 (8): 763–767.
doi :
10.1038/11698 .
PMC
5087329 .
PMID
10429240 .
^
Kimble, J. E. ;
White, J. G. (1981). "On the control of germ cell development in Caenorhabditis elegans". Developmental Biology . 81 (2): 208–219.
doi :
10.1016/0012-1606(81)90284-0 .
PMID
7202837 .
^ Chalfie, M.;
Eddy, S. ; Hengartner, M. O.;
Hodgkin, J. ; Kohara, Y.; Plasterk, R. H.; Waterston, R. H.;
White, J. G. (1995). "Genome maps. VI. Caenorhabditis elegans. Wall chart". Science . 270 (5235): 415–430.
doi :
10.1126/science.270.5235.410 .
PMID
7569996 .
S2CID
42933365 .
^
John G. White publications indexed by
Google Scholar
^ White, John (1975).
Computer aided reconstruction of the nervous system of Caenorhabditis elegans . cam.ac.uk (PhD thesis). University of Cambridge.
OCLC
500588370 .
EThOS
477040 .
^ Hyman, A. A.; White, J. G. (1987).
"Determination of cell division axes in the early embryogenesis of Caenorhabditis elegans" . The Journal of Cell Biology . 105 (5): 2123–2135.
doi :
10.1083/jcb.105.5.2123 .
PMC
2114830 .
PMID
3680373 .
^ Podbilewicz, B.;
White, J. G. (1994). "Cell fusions in the developing epithelial of C. Elegans". Developmental Biology . 161 (2): 408–424.
doi :
10.1006/dbio.1994.1041 .
PMID
8313992 .
^
White, J. ; Strome, S. (1996).
"Cleavage plane specification in C. Elegans: How to divide the spoils" . Cell . 84 (2): 195–198.
doi :
10.1016/s0092-8674(00)80974-5 .
PMID
8565065 .
^ O'Connell, K. F.; Leys, C. M.;
White, J. G. (1998).
"A genetic screen for temperature-sensitive cell-division mutants of Caenorhabditis elegans" . Genetics . 149 (3): 1303–1321.
doi :
10.1093/genetics/149.3.1303 .
PMC
1460235 .
PMID
9649522 .
^ Hird, S. N.;
White, J. G. (1993).
"Cortical and cytoplasmic flow polarity in early embryonic cells of Caenorhabditis elegans" . The Journal of Cell Biology . 121 (6): 1343–1355.
doi :
10.1083/jcb.121.6.1343 .
PMC
2119718 .
PMID
8509454 .
^ White, J. G.; Southgate, E.; Thomson, J. N.; Brenner, S. (1976).
"The structure of the ventral nerve cord of Caenorhabditis elegans" . Philosophical Transactions of the Royal Society of London. Series B, Biological Sciences . 275 (938): 327–348.
Bibcode :
1976RSPTB.275..327W .
doi :
10.1098/rstb.1976.0086 .
PMID
8806 .
^
a
b
White, J. G. ;
Southgate, E. ; Thomson, J. N.;
Brenner, S. (1986).
"The structure of the nervous system of the nematode Caenorhabditis elegans" . Philosophical Transactions of the Royal Society of London. Series B, Biological Sciences . 314 (1165): 1–340.
Bibcode :
1986RSPTB.314....1W .
doi :
10.1098/rstb.1986.0056 .
PMID
22462104 .
^
Sulston, J. ; Schierenberg, E.;
White, J. G. ; Thomson, J. (1983). "The embryonic cell lineage of the nematode Caenorhabditis elegans". Developmental Biology . 100 (1): 64–119.
doi :
10.1016/0012-1606(83)90201-4 .
PMID
6684600 .
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