From Wikipedia, the free encyclopedia
Frank Uhlmann
FRS
[1] is a group leader at the
Francis Crick Institute in London.
[6]
[7]
[8]
[9]
[10]
[11]
[12]
Education
Uhlmann was educated at the
University of Tübingen where he was awarded a PhD in 1997.
[4]
[13] During his PhD, he worked with
Jerard Hurwitz at the
Memorial Sloan Kettering Cancer Center in New York City.
[14]
[15]
[16]
Career
Following his PhD, Uhlmann moved to the
Research Institute of Molecular Pathology in Vienna for
postdoctoral research with
Kim Nasmyth . In 2000, he established a laboratory at the
Imperial Cancer Research Fund (now Cancer Research UK)
[17] in London, which ultimately became part of the Francis Crick Institute.
[16]
Awards and honours
Uhlmann was elected a
Fellow of the Royal Society (FRS) in 2015 . His certificate of election reads:
Frank Uhlmann's discovery with
Nasmyth of '
separase ', the
protease that cleaves the cohesive links between
sister chromatids to trigger
anaphase is a key contribution to our understanding of the
cell cycle . He has made major contributions to our understanding of the mechanisms of sister chromatid cohesion, and their relationship to cell cycle regulation. He generated the first
chromosome -wide high resolution maps of proteins involved in
chromosome packaging and segregation . He showed that
yeast
cohesins accumulate at sites of converging
transcription distinct from the sites where their loading factors bind, apparently reflecting interaction with the transcription apparatus; and that cohesin loading factors are recruited to specific chromosomal sites through interaction with the
nucleosome remodelling complex Rsc . He has identified genes required for cohesion establishment, and shown that one of these, EcoI,
acetylates cohesin during
DNA replication , thereby locking it onto DNA and his studies of the link between cohesion regulation and the cell cycle have shown that as well as cleaving cohesin, separase promotes
mitotic exit by activating the
Cdc14
phosphatase in a protease-independent manner.
[1]
In 2006, Uhlmann was also elected a member of the
European Molecular Biology Organization (EMBO)
[2] and awarded the
EMBO Gold Medal .
[5]
[3]
References
^
a
b
c
"Dr Frank Uhlmann FRS: Group Leader, The Francis Crick Institute" . London: The Royal Society. Archived from
the original on 2 May 2015.
^
a
b
"The EMBO Pocket Directory" (PDF) . European Molecular Biology Organization. Archived from
the original on 16 March 2015.
^
a
b Uhlmann, F. (2007).
"What is your assay for sister-chromatid cohesion?" . The EMBO Journal . 26 (22): 4609–4618.
doi :
10.1038/sj.emboj.7601898 .
PMC
2080813 .
PMID
17962808 .
^
a
b
"Frank Uhlmann: Mechanism and control of chromosome segregation" . The Crick Institute. Archived from
the original on 24 May 2015.
^
a
b
"Frank Uhlmann of London Research Institute wins 'EMBO Gold' " . EMBO. Archived from
the original on 14 April 2015.
^
Frank Uhlmann's publications indexed by the
Scopus bibliographic database. (subscription required)
^ Uhlmann, F; Lottspeich, F; Nasmyth, K (1999). "Sister-chromatid separation at anaphase onset is promoted by cleavage of the cohesin subunit Scc1". Nature . 400 (6739): 37–42.
Bibcode :
1999Natur.400...37U .
doi :
10.1038/21831 .
PMID
10403247 .
S2CID
4354549 .
^
Uhlmann, F ; Wernic, D; Poupart, M. A.;
Koonin, E. V. ;
Nasmyth, K (2000).
"Cleavage of cohesin by the CD clan protease separin triggers anaphase in yeast" .
Cell . 103 (3): 375–86.
doi :
10.1016/s0092-8674(00)00130-6 .
PMID
11081625 .
S2CID
2667617 .
^ Tóth, A; Ciosk, R;
Uhlmann, F ; Galova, M; Schleiffer, A;
Nasmyth, K (1999).
"Yeast cohesin complex requires a conserved protein, Eco1p(Ctf7), to establish cohesion between sister chromatids during DNA replication" . Genes & Development . 13 (3): 320–33.
doi :
10.1101/gad.13.3.320 .
PMC
316435 .
PMID
9990856 .
^
Nasmyth, K ; Peters, J. M.;
Uhlmann, F (2000). "Splitting the chromosome: Cutting the ties that bind sister chromatids". Science . 288 (5470). New York, N.Y.: 1379–85.
Bibcode :
2000Sci...288.1379N .
doi :
10.1126/science.288.5470.1379 .
PMID
10827941 .
^ Godfrey, M; Kuilman, T;
Uhlmann, F (2015).
"Nur1 dephosphorylation confers positive feedback to mitotic exit phosphatase activation in budding yeast" .
PLOS Genetics . 11 (1): e1004907.
doi :
10.1371/journal.pgen.1004907 .
PMC
4287440 .
PMID
25569132 .
^ Cheng, T. M.; Heeger, S; Chaleil, R. A.; Matthews, N; Stewart, A; Wright, J; Lim, C; Bates, P. A.;
Uhlmann, F (2015).
"A simple biophysical model emulates budding yeast chromosome condensation" .
eLife . 4 : e05565.
doi :
10.7554/eLife.05565 .
PMC
4413874 .
PMID
25922992 .
^ Uhlmann, Frank (1997).
Reconstitution and characterization of human replication factor C (PhD thesis). University of Tübingen.
OCLC
51443586 .
^ Uhlmann, F; Gibbs, E; Cai, J; O'Donnell, M; Hurwitz, J (1997).
"Identification of regions within the four small subunits of human replication factor C required for complex formation and DNA replication" . The Journal of Biological Chemistry . 272 (15): 10065–71.
doi :
10.1074/jbc.272.15.10065 .
PMID
9092550 .
^ Uhlmann, F; Cai, J; Flores-Rozas, H; Dean, F. B.; Finkelstein, J; O'Donnell, M; Hurwitz, J (1996).
"In vitro reconstitution of human replication factor C from its five subunits" . Proceedings of the National Academy of Sciences of the United States of America . 93 (13): 6521–6.
Bibcode :
1996PNAS...93.6521U .
doi :
10.1073/pnas.93.13.6521 .
PMC
39056 .
PMID
8692848 .
^
a
b
"Frank Uhlmann biography" . London: Francis Crick Institute. Archived from
the original on 25 May 2015.
^
"Frank Uhlmann: Understanding how cells divide" . Cancer Research UK. Archived from
the original on 27 May 2015.
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