American biologist
"Koonin" redirects here. For the American theoretical physicist, see
Steven E. Koonin .
Eugene Viktorovich Koonin (Russian: Евге́ний Ви́кторович Ку́нин; born October 26, 1956) is a Russian-American biologist and Senior Investigator at the
National Center for Biotechnology Information (NCBI). He is a recognised expert in the field of
evolutionary and
computational biology .
[1]
[2]
[3]
Education
Koonin gained a
Master of Science in 1978 and a
PhD in 1983 in
molecular biology , both from the Department of Biology at
Moscow State University . His PhD thesis, titled "Multienzyme organization of encephalomyocarditis virus replication complexes", was supervised by
Vadim I. Agol .
[4]
Research
From 1985 until 1991, Koonin worked as a research scientist in computational biology in the Institutes of
Poliomyelitis and Microbiology at the
USSR Academy of Medical Sciences , studying virus biochemistry and bacterial genetics. In 1991, Koonin moved to the NCBI, where he has held a Senior Investigator position since 1996.
[4]
Koonin's principal research goals include the comparative analysis of sequenced genomes and automatic methods for genome-scale annotation of gene functions.
[5] He also researches in the application of comparative
genomics for phylogenetic analysis, reconstruction of ancestral life forms and building large-scale evolutionary scenarios, as well as mathematical modeling of
genome evolution .
[6]
[7]
[8] Koonin's research also investigates computational study of the major transitions in the evolution of life, such as the origin of
eukaryotes ,
[9] the evolution of eukaryotic signaling and developmental pathways from the comparative-genomic perspective.
[10]
Koonin is an advocate of the
extended evolutionary synthesis .
[11]
In 2011 Koonin outlined his views on evolution in the book "The Logic of Chance: The Nature and Origin of Biological Evolution".
[2]
Career
Koonin has worked as Adjunct Professor at the
Georgia Institute of Technology ,
Boston University and the
University of Haifa .
[4]
[12]
As of 2014, Koonin serves on the advisory editorial board of
Trends in Genetics ,
[13] and is co-Editor-in-Chief of the open access journal
Biology Direct .
[14] He served on the editorial board of
Bioinformatics from 1999 until 2001. Koonin is also an advisory board member in bioinformatics at
Faculty of 1000 .
[15]
In 2016 he was elected to the
National Academy of Sciences .
[16]
[17]
In 2016,
Semantic Scholar AI program included Koonin on its list of top ten most influential biomedical researchers.
[18]
Political positions
In February 2022, he signed an open letter by Russian scientists condemning the
2022 Russian invasion of Ukraine ,
[19] and renounced his membership in the
Russian Academy of Sciences out of protest.
[20]
References
^
https://www.ncbi.nlm.nih.gov/CBBresearch/Koonin/ Koonin's page at the National Center for Biotechnology Information
^
a
b Eugene V. Koonin (23 June 2011).
The Logic of Chance: The Nature and Origin of Biological Evolution . FT Press.
ISBN
978-0-13-262317-9 . Retrieved 5 April 2013 .
^ Koonin, E. V. (2004).
"Eugene V. Koonin" . Current Biology . 14 (3): R96–97.
doi :
10.1016/j.cub.2004.01.010 .
PMID
14986627 .
^
a
b
c
"CV E. Koonin" . Haifa Institute of Evolution . Archived from
the original on 29 July 2019. Retrieved 28 July 2020 .
^
Lander, E. S. ; Linton, M.; Birren, B.; Nusbaum, C.; Zody, C.; Baldwin, J.; Devon, K.; Dewar, K.; Doyle, M.; Fitzhugh, W.; Funke, R.; Gage, D.; Harris, K.; Heaford, A.; Howland, J.; Kann, L.; Lehoczky, J.; Levine, R.; McEwan, P.; McKernan, K.; Meldrim, J.; Mesirov, J. P.; Miranda, C.; Morris, W.; Naylor, J.; Raymond, C.; Rosetti, M.; Santos, R.; Sheridan, A.; et al. (Feb 2001).
"Initial sequencing and analysis of the human genome" (PDF) . Nature . 409 (6822): 860–921.
Bibcode :
2001Natur.409..860L .
doi :
10.1038/35057062 .
ISSN
0028-0836 .
PMID
11237011 .
^
Koonin, E. V. (2011). Bourne, Philip E. (ed.).
"Are There Laws of Genome Evolution?" .
PLOS Computational Biology . 7 (8): e1002173.
arXiv :
1108.3589 .
Bibcode :
2011PLSCB...7E2173K .
doi :
10.1371/journal.pcbi.1002173 .
PMC
3161903 .
PMID
21901087 .
^
Koonin, E. V. (2007).
"The Biological Big Bang model for the major transitions in evolution" . Biology Direct . 2 : 21.
doi :
10.1186/1745-6150-2-21 .
PMC
1973067 .
PMID
17708768 .
^
Koonin, E. V. ; Senkevich, T. G.; Dolja, V. V. (2006).
"The ancient Virus World and evolution of cells" . Biology Direct . 1 : 29.
doi :
10.1186/1745-6150-1-29 .
PMC
1594570 .
PMID
16984643 .
^ Martin, William; Koonin, Eugene V. (2006). "Introns and the origin of nucleus–cytosol compartmentalization". Nature . 440 (7080): 41–45.
doi :
10.1038/nature04531 .
ISSN
0028-0836 .
^
Uhlmann, F ; Wernic, D; Poupart, M. A.;
Koonin, E. V. ;
Nasmyth, K (2000).
"Cleavage of cohesin by the CD clan protease separin triggers anaphase in yeast" .
Cell . 103 (3): 375–386.
doi :
10.1016/s0092-8674(00)00130-6 .
PMID
11081625 .
S2CID
2667617 .
^ Svensson, Erik I. (2023).
"The Structure of Evolutionary Theory: Beyond Neo-Darwinism, Neo-Lamarckism and Biased Historical Narratives About the Modern Synthesis" . Evolutionary Biology: Contemporary and Historical Reflections Upon Core Theory . Evolutionary Biology – New Perspectives on Its Development. Vol. 6. pp. 173–217.
doi :
10.1007/978-3-031-22028-9_11 .
ISBN
978-3-031-22027-2 .
^
"Faculty and Researchers" . Haifa Institute of Evolution . Archived from
the original on 1 August 2019. Retrieved 28 July 2020 .
^
"Masthead: Trends in Genetics" . cell.com . Retrieved 3 September 2014 .
^
"Biology Direct – Editorial Board" . biologydirect.com . Retrieved 3 September 2014 .
^
"Eugene Koonin: Advisory Board Member in Bioinformatics – F1000Prime" . f1000.com . Retrieved 3 September 2014 .
^
National Academy of Sciences Members and Foreign Associates Elected , News from the National Academy of Sciences,
National Academy of Sciences , May 3, 2016, archived from
the original on May 6, 2016, retrieved 2016-05-14 .
^ Gabrielsen, Paul (2017-01-31).
"Profile of Eugene V. Koonin" .
Proceedings of the National Academy of Sciences of the United States of America . 114 (5): 793–796.
Bibcode :
2017PNAS..114..793G .
doi :
10.1073/pnas.1621406114 .
ISSN
0027-8424 .
PMC
5293061 .
PMID
28115717 .
^ Chawla, Dalmeet Singh (17 October 2017).
"Who's the most influential biomedical scientist? Computer program guided by artificial intelligence says it knows" . Science | AAAS . Retrieved 2022-02-16 .
^
"Открытое письмо российских учёных и научных журналистов против войны с Украиной" [An open letter from Russian scientists and scientific journalist against the war in Ukraine] (in Russian). 24 February 2022. Retrieved 2 April 2022 .
^
"Global Science Community Condemns Russian Invasion of Ukraine" .
Scientific American .
Archived from the original on 2023-03-12.
Selected bibliography
Dolja, Valerian V.; Krupovic, Mart;
Koonin, Eugene V. (2020-08-25).
"Deep Roots and Splendid Boughs of the Global Plant Virome" (PDF) .
Annual Review of Phytopathology . 58 (1).
Annual Reviews : 23–53.
doi :
10.1146/annurev-phyto-030320-041346 .
ISSN
0066-4286 .
PMID
32459570 .
S2CID
218974980 .
HAL Id :
02861246 .
Dolja, Valerian V.; Karasev, Alexander V.; Koonin, Eugene V. (1994). "Molecular Biology and Evolution of Closteroviruses: Sophisticated Build-up of Large RNA Genomes".
Annual Review of Phytopathology . 32 (1).
Annual Reviews : 261–285.
doi :
10.1146/annurev.py.32.090194.001401 .
ISSN
0066-4286 .
Makarova, Kira S.; Wolf, Yuri I.; Alkhnbashi, Omer S.; Costa, Fabrizio; Shah, Shiraz A.; Saunders, Sita J.; Barrangou, Rodolphe; Brouns, Stan J. J.;
Charpentier, Emmanuelle ; Haft, Daniel H.; Horvath, Philippe; Moineau, Sylvain; Mojica, Francisco J. M.; Terns, Rebecca M.; Terns, Michael P.; White, Malcolm F.; Yakunin, Alexander F.; Garrett, Roger A.; van der Oost, John; Backofen, Rolf;
Koonin, Eugene V. (2015-09-28).
"An updated evolutionary classification of CRISPR–Cas systems" .
Nature Reviews Microbiology . 13 (11).
Nature Portfolio : 722–736.
doi :
10.1038/nrmicro3569 .
ISSN
1740-1526 .
PMC
5426118 .
PMID
26411297 .
Gabaldón, Toni;
Koonin, Eugene V. (2013-04-04).
"Functional and evolutionary implications of gene orthology" .
Nature Reviews Genetics . 14 (5).
Nature Portfolio : 360–366.
doi :
10.1038/nrg3456 .
ISSN
1471-0056 .
PMC
5877793 .
PMID
23552219 .
External links
International National Academics Other