Fibulin-1 has modular domain structure and includes a series of nine
epidermal growth factor-like modules followed by a
fibulin-type module, a module found in all members of the fibulin gene family.[6]
The human fibulin-1 gene, FBLN1, encodes four
splice variants designated fibulin-1A, B, C and D, which differ in their
carboxy terminal regions. In mouse, chicken and the nematode, C. elegans, only two fibulin-1 variants are produced, fibulin-1C and fibulin-1D.[5]
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