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EIF4G1
Available structures
PDBOrtholog search: PDBe RCSB
Identifiers
Aliases EIF4G1, EIF-4G1, EIF4F, EIF4G, EIF4GI, P220, PARK18, Eukaryotic translation initiation factor 4 gamma, eukaryotic translation initiation factor 4 gamma 1
External IDs OMIM: 600495 MGI: 2384784 HomoloGene: 110725 GeneCards: EIF4G1
Orthologs
SpeciesHumanMouse
Entrez

1981

208643

Ensembl

ENSG00000114867

ENSMUSG00000045983

UniProt

Q04637

Q6NZJ6

RefSeq (mRNA)

NM_001005331
NM_145941
NM_001304432

RefSeq (protein)
Location (UCSC) Chr 3: 184.31 – 184.34 Mb Chr 16: 20.49 – 20.51 Mb
PubMed search [3] [4]
Wikidata
View/Edit Human View/Edit Mouse

Eukaryotic translation initiation factor 4 gamma 1 is a protein that in humans is encoded by the EIF4G1 gene. [5] [6]

Function

The protein encoded by this gene is a component of the protein complex eIF4F, which is involved in the recognition of the mRNA cap, ATP-dependent unwinding of 5'-terminal secondary structure, and recruitment of mRNA to the ribosome. Alternative splicing results in five transcript variants encoding four distinct isoforms. [7] eIF4G serves as a scaffold, interacting with mRNA and the other components of the eIF4F complex, as well as the PABP and eIF3.

Interactions

Eukaryotic translation initiation factor 4 gamma has been shown to interact with MKNK1, [8] EIF4A1, [9] [10] [11] EIF4E, [10] [11] [12] [13] [14] MKNK2 [15] and PABPC1. [16]

See also

References

  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000114867 – Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000045983 – Ensembl, May 2017
  3. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. ^ Yan R, Rychlik W, Etchison D, Rhoads RE (Nov 1992). "Amino acid sequence of the human protein synthesis initiation factor eIF-4 gamma". The Journal of Biological Chemistry. 267 (32): 23226–31. doi: 10.1016/S0021-9258(18)50080-6. PMID  1429670.
  6. ^ Imataka H, Sonenberg N (Dec 1997). "Human eukaryotic translation initiation factor 4G (eIF4G) possesses two separate and independent binding sites for eIF4A". Molecular and Cellular Biology. 17 (12): 6940–7. doi: 10.1128/mcb.17.12.6940. PMC  232551. PMID  9372926.
  7. ^ "Entrez Gene: EIF4G1 eukaryotic translation initiation factor 4 gamma, 1".
  8. ^ Pyronnet S, Imataka H, Gingras AC, Fukunaga R, Hunter T, Sonenberg N (Jan 1999). "Human eukaryotic translation initiation factor 4G (eIF4G) recruits mnk1 to phosphorylate eIF4E". The EMBO Journal. 18 (1): 270–9. doi: 10.1093/emboj/18.1.270. PMC  1171121. PMID  9878069.
  9. ^ Ewing RM, Chu P, Elisma F, Li H, Taylor P, Climie S, McBroom-Cerajewski L, Robinson MD, O'Connor L, Li M, Taylor R, Dharsee M, Ho Y, Heilbut A, Moore L, Zhang S, Ornatsky O, Bukhman YV, Ethier M, Sheng Y, Vasilescu J, Abu-Farha M, Lambert JP, Duewel HS, Stewart II, Kuehl B, Hogue K, Colwill K, Gladwish K, Muskat B, Kinach R, Adams SL, Moran MF, Morin GB, Topaloglou T, Figeys D (2007). "Large-scale mapping of human protein-protein interactions by mass spectrometry". Molecular Systems Biology. 3 (1): 89. doi: 10.1038/msb4100134. PMC  1847948. PMID  17353931.
  10. ^ a b Connolly E, Braunstein S, Formenti S, Schneider RJ (May 2006). "Hypoxia inhibits protein synthesis through a 4E-BP1 and elongation factor 2 kinase pathway controlled by mTOR and uncoupled in breast cancer cells". Molecular and Cellular Biology. 26 (10): 3955–65. doi: 10.1128/MCB.26.10.3955-3965.2006. PMC  1489005. PMID  16648488.
  11. ^ a b Harris TE, Chi A, Shabanowitz J, Hunt DF, Rhoads RE, Lawrence JC (Apr 2006). "mTOR-dependent stimulation of the association of eIF4G and eIF3 by insulin". The EMBO Journal. 25 (8): 1659–68. doi: 10.1038/sj.emboj.7601047. PMC  1440840. PMID  16541103.
  12. ^ Vary TC, Jefferson LS, Kimball SR (Dec 1999). "Amino acid-induced stimulation of translation initiation in rat skeletal muscle". The American Journal of Physiology. 277 (6 Pt 1): E1077–86. doi: 10.1152/ajpendo.1999.277.6.E1077. PMID  10600798. S2CID  4516850.
  13. ^ Mader S, Lee H, Pause A, Sonenberg N (Sep 1995). "The translation initiation factor eIF-4E binds to a common motif shared by the translation factor eIF-4 gamma and the translational repressors 4E-binding proteins". Molecular and Cellular Biology. 15 (9): 4990–7. doi: 10.1128/MCB.15.9.4990. PMC  230746. PMID  7651417.
  14. ^ Kumar V, Sabatini D, Pandey P, Gingras AC, Majumder PK, Kumar M, Yuan ZM, Carmichael G, Weichselbaum R, Sonenberg N, Kufe D, Kharbanda S (Apr 2000). "Regulation of the rapamycin and FKBP-target 1/mammalian target of rapamycin and cap-dependent initiation of translation by the c-Abl protein-tyrosine kinase". The Journal of Biological Chemistry. 275 (15): 10779–87. doi: 10.1074/jbc.275.15.10779. PMID  10753870.
  15. ^ Scheper GC, Parra JL, Wilson M, Van Kollenburg B, Vertegaal AC, Han ZG, Proud CG (Aug 2003). "The N and C termini of the splice variants of the human mitogen-activated protein kinase-interacting kinase Mnk2 determine activity and localization". Molecular and Cellular Biology. 23 (16): 5692–705. doi: 10.1128/MCB.23.16.5692-5705.2003. PMC  166352. PMID  12897141.
  16. ^ Imataka H, Gradi A, Sonenberg N (Dec 1998). "A newly identified N-terminal amino acid sequence of human eIF4G binds poly(A)-binding protein and functions in poly(A)-dependent translation". The EMBO Journal. 17 (24): 7480–9. doi: 10.1093/emboj/17.24.7480. PMC  1171091. PMID  9857202.

Further reading

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