From Wikipedia, the free encyclopedia
Ethanolamine-O -sulfate
[1]
Names
Preferred IUPAC name
2-Aminoethyl hydrogen sulfate
Other names
Aminoethyl sulfate; 2-Aminoethyl hydrogen sulphate; Sulfuric acid mono 2-aminoethyl ester; WAS-34
Identifiers
Abbreviations
EOS
ChemSpider
ECHA InfoCard
100.011.942
EC Number
UNII
InChI=1S/C2H7NO4S/c3-1-2-7-8(4,5)6/h1-3H2,(H,4,5,6)
N Key: WSYUEVRAMDSJKL-UHFFFAOYSA-N
N
Properties
C 2 H 7 N O 4 S
Molar mass
141.14 g·mol−1
Melting point
277 °C (531 °F; 550 K) (decomposes)
Hazards
GHS labelling :
Warning
H302 ,
H315 ,
H319 ,
H335
Except where otherwise noted, data are given for materials in their
standard state (at 25 °C [77 °F], 100 kPa).
Chemical compound
Ethanolamine-O -sulfate (EOS) is an
ester of
sulfuric acid and
ethanolamine . EOS is a
GABA transaminase inhibitor which prevents the metabolism of
GABA .
[2] It is used as a biochemical tool in studies involving GABA.
EOS is also a
diuretic
[3] and an
anticonvulsant .
[4]
References
^
2-Aminoethyl hydrogen sulfate at
Sigma-Aldrich
^ Gudelsky GA, Apud JA, Masotto C, Locatelli V, Cocchi D, Racagni G, Muller EE (1983). "Ethanolamine-O-sulfate enhances gamma-aminobutyric acid secretion into hypophysial portal blood and lowers serum prolactin concentrations". Neuroendocrinology . 37 (5): 397–9.
doi :
10.1159/000123580 .
PMID
6646351 .
^ German Patent DE2345291: Diuretic aminoalkyl sulfates; Somani, Pitambar; Martin, Donald Lyons (1974)
^ Anlezark, Gill; Horton, Roger W.; Meldrum, Brian S.; Sawaya, M. Christina B. (1976). "Anticonvulsant action of ethanolamine-O-sulfate and di-n-propylacetate and the metabolism of γ-aminobutyric acid (GABA) in mice with audiogenic seizures".
Biochemical Pharmacology . 25 (4): 413–417.
doi :
10.1016/0006-2952(76)90343-9 .
PMID
779794 .
Transporter
GAT Tooltip GABA transporter
VIAAT Tooltip Vesicular inhibitory amino acid transporter
Enzyme
GAD Tooltip Glutamate decarboxylase
GABA-T Tooltip γ-Aminobutyrate aminotransferase
Other