Combination of | |
---|---|
Hydrochlorothiazide | Thiazide diuretic |
Triamterene | Potassium-sparing diuretic |
Clinical data | |
Trade names | Dyazide, Maxzide, others |
Other names | co-triamterzide |
AHFS/ Drugs.com | Professional Drug Facts |
License data | |
Pregnancy category |
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Routes of administration | By mouth |
ATC code | |
Legal status | |
Legal status | |
Identifiers | |
CAS Number | |
KEGG |
Hydrochlorothiazide/triamterene, also known as co-triamterzide, is a fixed-dose combination medication of hydrochlorothiazide and triamterene. [2] [3] [4] It is used to treat high blood pressure and edema (swelling). [2] [3] [4] Specifically it is used in those who develop low blood potassium (hypokalemia) when on only hydrochlorothiazide. [2] [3] It is taken by mouth. [2] [3] [4]
Side effects may include nausea, trouble sleeping, dizziness, feeling light headed with standing, kidney problems, allergies, and muscle cramps. [2] [3] Other serious side effects may include high blood potassium. [2] [3] Use in pregnancy and breastfeeding is not generally recommended. [2] [3] Use in those with significant kidney problems is not recommended. [2] [3] It decreases blood pressure mainly by hydrochlorothiazide while triamterene decreases the amount of potassium lost. [2] [3]
The combination was approved for medical use in the United States in 1965. [5] In 2021, it was the 112th most commonly prescribed medication in the United States, with more than 5 million prescriptions. [6] [7]