Although there is a widely quoted cross-allergy risk of 10% between cephalosporins and penicillin, research has shown no increased risk for cross-allergy for cefprozil and several other second-generation or later cephalosporins.[6] The most common side effects were increased hepatic lab values (including AST and ALGT), dizziness, eosinophilia, diaper rash and superinfection, genital pruritus, vaginitis, diarrhea, nausea, vomiting, and abdominal pain.[5]
Spectrum of bacterial susceptibility and resistance
This is not a direct copy of Lednicer book like at first glance, but is sourced from the primary reference material.
Displacement of the allylic chloride in intermediate (1) with
triphenylphosphine gives the phosphonium salt (2). This functionality is then converted to its
ylide; condensation with
acetaldehyde then leads to the
vinyl derivative (3); deprotection then gives cefprozil. Semisynthetic oral cephalosporin consisting of ~90:10 Z/E isomeric mixture.[12][13]
^Albanus L, Björklund NE, Gustafsson B, Jönsson M (1975). "Forty days oral toxicity of 2,6-cis-diphenylhexamethylcyclotetrasiloxane (KABI 1774)in beagle dogs with special reference to effects on the male reproductive system". Acta Pharmacologica et Toxicologica. 36 (Suppl 3): 93–130.
doi:
10.1111/j.1600-0773.1975.tb03087.x.
PMID1080338.