Clinical data | |
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AHFS/ Drugs.com | International Drug Names |
MedlinePlus | a682860 |
Pregnancy category |
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Routes of administration | Intravenous |
ATC code | |
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Pharmacokinetic data | |
Bioavailability | n/a |
Protein binding | 65 to 80% |
Metabolism | Hepatic |
Elimination half-life | 30 minutes to 1 hour |
Excretion | Renal |
Identifiers | |
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CAS Number | |
PubChem CID | |
DrugBank | |
ChemSpider | |
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ChEBI | |
ChEMBL | |
CompTox Dashboard ( EPA) | |
ECHA InfoCard | 100.005.288 |
Chemical and physical data | |
Formula | C16H16N2O6S2 |
Molar mass | 396.43 g·mol−1 |
3D model ( JSmol) | |
Melting point | 160 to 160.5 °C (320.0 to 320.9 °F) |
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Cefalotin ( INN) /ˌsɛfəˈloʊtɪn/ or cephalothin ( USAN) /ˌsɛfəˈloʊθɪn/ is a first-generation cephalosporin antibiotic with broad spectrum antibiotic activity. [1] [2] It was the first cephalosporin marketed (1964) and continues to be widely used. [3] Cefalotin is used for bacterial infections of the respiratory tract, urinary tract, skin, soft tissues, bones and joints, sepsis, peritonitis, osteomyelitis, mastitis, infected wounds, and post-operational infections. [2]
It is an intravenously administered agent with a similar antimicrobial spectrum to cefazolin and the oral agent cefalexin. Cefalotin sodium is marketed as Keflin ( Lilly) and under other trade names. [4]
The compound is a derivative of thiophene-2-acetic acid. [5]